{"id":"W4407235444","doi":"10.1161/circulationaha.124.072384","title":"Ezh2 Shapes T Cell Plasticity to Drive Atherosclerosis","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers; National Institutes of Health; Berlin Institute of Health; Bundesministerium für Bildung und Forschung; ZonMw; Fondation Leducq; Deutsche Forschungsgemeinschaft; Amsterdam University Medical Centers; Deutsches Zentrum für Herz-Kreislaufforschung","keywords":"EZH2; CCL5; T cell; Immune system; CD8; Chemokine; Cancer research; Inflammation; Biology; Immunology; Cell biology; Epigenetics; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001384645,0.000312948,0.0002105026,0.0002214675,0.0002079828,0.000484631,0.0002178996,0.0004561709,0.002494469],"category_scores_gemma":[0.0002144377,0.0001668631,0.000167269,0.00009845448,0.0002716714,0.0003450054,0.0004310698,0.0006622754,0.0007912272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003181108,"about_ca_system_score_gemma":0.000181217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002419115,"about_ca_topic_score_gemma":0.0005468912,"domain_scores_codex":[0.9998279,0.0000197905,0.000009538479,0.00004485848,0.00003735969,0.00006065684],"domain_scores_gemma":[0.9998596,0.00001398777,0.00003349422,0.00001298096,0.0000197296,0.00006015533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000161391,0.00001587952,0.001179945,0.00005281032,0.000008767171,0.0001034043,0.00003318169,0.000168786,0.9944181,0.0005787265,0.0004039799,0.002875141],"study_design_scores_gemma":[0.0001290291,0.0005705415,0.03151632,0.0000348092,0.00009095868,0.0007517443,0.0003466363,0.006878191,0.9336702,0.001551316,0.02443359,0.00002685041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884201,0.001570073,0.004419575,0.0004380538,0.0001065064,0.00002693388,0.0003263082,0.0002333352,0.004458969],"genre_scores_gemma":[0.9950442,0.00048906,0.0009615745,0.0001494833,0.00004157949,0.00002064999,0.0001961677,0.00003074916,0.003066507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002494469,"threshold_uncertainty_score":0.008344769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080301801791387,"score_gpt":0.2196045071376763,"score_spread":0.2088014891197625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}