{"id":"W4407235444","doi":"10.1161/circulationaha.124.072384","title":"Ezh2 Shapes T Cell Plasticity to Drive Atherosclerosis","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers; National Institutes of Health; Berlin Institute of Health; Bundesministerium für Bildung und Forschung; ZonMw; Fondation Leducq; Deutsche Forschungsgemeinschaft; Amsterdam University Medical Centers; Deutsches Zentrum für Herz-Kreislaufforschung","keywords":"EZH2; CCL5; T cell; Immune system; CD8; Chemokine; Cancer research; Inflammation; Biology; Immunology; Cell biology; Epigenetics; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000895362,0.0001308134,0.000193436,0.00008475169,0.0001953787,0.00002559953,0.0001295887,0.0001429535,0.000276458],"category_scores_gemma":[0.00005178533,0.0001278904,0.000193461,0.0002096552,0.00004888298,0.00006027157,0.00005864004,0.00008437166,0.0006986458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005738301,"about_ca_system_score_gemma":0.00003575236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002880342,"about_ca_topic_score_gemma":0.000005021063,"domain_scores_codex":[0.9991854,0.0000908348,0.0001745359,0.0002997888,0.00003975099,0.0002096435],"domain_scores_gemma":[0.9996361,0.00005827195,0.00004155337,0.0001721056,0.0000671817,0.00002474748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002900975,0.0001300107,0.08285437,0.00002310545,0.0001754652,2.244938e-7,0.0002411171,0.001619848,0.9046097,0.001536735,0.002133999,0.006646429],"study_design_scores_gemma":[0.0006185336,0.00001810134,0.9506508,0.00004935357,0.0001219622,5.72229e-7,0.00009892402,0.00004399352,0.04100431,0.0001767262,0.007068152,0.000148595],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974156,0.0008202606,0.0207324,0.00009376456,0.0003275793,0.0002741583,0.00002413953,0.0001039572,0.003467752],"genre_scores_gemma":[0.9989985,0.00002121327,0.00004702253,0.0003743323,0.0000245761,0.00004434427,0.00003466608,0.00001141395,0.0004439872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8677964,"threshold_uncertainty_score":0.8979911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080301801791387,"score_gpt":0.2196045071376763,"score_spread":0.2088014891197625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}