{"id":"W4407239061","doi":"10.1128/spectrum.01006-24","title":"Mecillinam activity against multidrug-resistant <i>Shigella sonnei</i> and <i>Shigella flexneri</i>","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia; Providence Health Care","funders":"","keywords":"Shigella sonnei; Shigella flexneri; Shigella; Microbiology; Mecillinam; Multiple drug resistance; Shigellosis; Biology; Enterobacteriaceae; Medicine; Drug resistance; Bacteria; Escherichia coli; Salmonella; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003496129,0.0003796363,0.0004160177,0.0001050286,0.000341796,0.00004468337,0.0003599403,0.0003444107,0.00001248263],"category_scores_gemma":[0.0001476401,0.0003498629,0.0001375743,0.00022987,0.0006152194,0.000005610374,0.0007519996,0.0003317322,0.00002246482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000592977,"about_ca_system_score_gemma":0.0001646624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006119059,"about_ca_topic_score_gemma":0.000722584,"domain_scores_codex":[0.9978018,0.0002306962,0.0002681373,0.000872088,0.00006610654,0.0007611276],"domain_scores_gemma":[0.9990706,0.00007472312,0.00009528297,0.0005748564,0.00007447058,0.0001099929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004486651,0.0001164862,0.002703764,0.00005511623,0.0002287215,0.00001292116,0.00002997723,0.00001048823,0.9884064,0.0002233961,0.006871428,0.0008927012],"study_design_scores_gemma":[0.001051274,0.0003316835,0.003335437,0.00003065526,0.00003024476,0.00001299895,0.00008283331,0.00003979943,0.7424937,0.0001223261,0.2520832,0.0003858521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834519,0.004214763,0.0003190792,0.00268822,0.0003044285,0.0004114703,0.0001099804,0.00005256575,0.008447591],"genre_scores_gemma":[0.9908482,0.002483768,0.000569438,0.001439628,0.0001639059,0.00004822082,0.00009035517,0.00003178449,0.004324721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2459126,"threshold_uncertainty_score":0.9998953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005007475020679695,"score_gpt":0.2435591456310857,"score_spread":0.238551670610406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}