{"id":"W4407239061","doi":"10.1128/spectrum.01006-24","title":"Mecillinam activity against multidrug-resistant <i>Shigella sonnei</i> and <i>Shigella flexneri</i>","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia; Providence Health Care","funders":"","keywords":"Shigella sonnei; Shigella flexneri; Shigella; Microbiology; Mecillinam; Multiple drug resistance; Shigellosis; Biology; Enterobacteriaceae; Medicine; Drug resistance; Bacteria; Escherichia coli; Salmonella; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002704874,0.0002330845,0.0002154501,0.0002550769,0.0001044618,0.0001680759,0.0001823301,0.0001431763,0.0006921382],"category_scores_gemma":[0.000596869,0.00008597613,0.0002216669,0.000199606,0.0001449283,0.0001483721,0.0001712852,0.0001416847,0.0001204484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001168977,"about_ca_system_score_gemma":0.0001260209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001496551,"about_ca_topic_score_gemma":0.001451754,"domain_scores_codex":[0.9997347,0.00007732868,0.0000477447,0.00004250254,0.00005988955,0.00003769752],"domain_scores_gemma":[0.9996367,0.0001084867,0.00008350363,0.00002964994,0.0001006714,0.00004099277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006907305,0.0001207223,0.07056794,0.0002338268,0.00008188008,0.0002295727,0.0002086272,0.0002484835,0.9137871,0.00003657084,0.0001257218,0.0136689],"study_design_scores_gemma":[0.00006231527,0.004306594,0.4067777,0.00005398371,0.0002294252,0.00198594,0.0005082625,0.0007587764,0.5826576,0.00004657549,0.002586541,0.00002637472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998936,0.0004658242,0.0001694971,0.0000192817,0.000003519532,0.000008296935,0.0001573868,0.000005343953,0.0002348537],"genre_scores_gemma":[0.9983359,0.0002514619,0.0007484616,0.00002523153,0.000004214332,0.000007477912,0.0004921004,0.00000388448,0.0001313494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001496551,"threshold_uncertainty_score":0.002975702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005007475020679695,"score_gpt":0.2435591456310857,"score_spread":0.238551670610406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}