{"id":"W4407239669","doi":"10.1016/j.stem.2025.01.001","title":"Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions","year":2025,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children; University of British Columbia; University of Ottawa; Canada's Michael Smith Genome Sciences Centre; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada First Research Excellence Fund; Canada Research Chairs","keywords":"Neural stem cell; Biology; Stem cell; Cell biology; Niche; Subventricular zone; Optogenetics; Stem cell niche; Mechanism (biology); Neuroscience; Cell fate determination; Neurogenesis; Progenitor cell; Transcription factor; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001711304,0.0002190935,0.0003303407,0.0003981501,0.000237916,0.0008196224,0.0003518885,0.0001895487,0.001405737],"category_scores_gemma":[0.0004337624,0.0001554213,0.0001762386,0.0002150093,0.0003815954,0.0005118299,0.0004547592,0.0004737017,0.0003236413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003355596,"about_ca_system_score_gemma":0.0003558061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007216302,"about_ca_topic_score_gemma":0.001798858,"domain_scores_codex":[0.9998011,0.00002250641,0.00001360363,0.00004250835,0.00005464832,0.00006558943],"domain_scores_gemma":[0.999725,0.00004988021,0.00006079219,0.0000220858,0.0000522484,0.00008994963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005340209,0.00004074911,0.003438426,0.00002618615,0.000008074864,0.00009046795,0.0001492894,0.0001389297,0.9880497,0.0009969396,0.000104949,0.006422163],"study_design_scores_gemma":[0.00003909741,0.0003383021,0.09299928,0.00001800543,0.00004473175,0.000272048,0.0006488358,0.006084679,0.8956763,0.001087121,0.002769626,0.0000218811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954912,0.0008078314,0.002027512,0.00005253088,0.00001461529,0.00000618574,0.0001366696,0.00005565463,0.001407843],"genre_scores_gemma":[0.9980751,0.00022092,0.000468942,0.00002006376,0.000008091939,0.00001479455,0.0001481101,0.00002743801,0.001016596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001405737,"threshold_uncertainty_score":0.004702687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914334961737543,"score_gpt":0.2288455210629227,"score_spread":0.2097021714455473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}