{"id":"W4407240463","doi":"10.3390/cancers17040569","title":"K-Means Clustering of Hyperpolarised 13C-MRI Identifies Intratumoral Perfusion/Metabolism Mismatch in Renal Cell Carcinoma as the Best Predictor of the Highest Grade","year":2025,"lang":"en","type":"article","venue":"Cancers","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Cambridge Biomedical Research Centre; Mark Foundation For Cancer Research; Lundbeckfonden; Cancer Research UK; Canadian Institute for Advanced Research","keywords":"Clear cell renal cell carcinoma; Renal cell carcinoma; Medicine; Biopsy; Perfusion; Magnetic resonance imaging; Radiology; Pathology; Nuclear medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009157634,0.000675128,0.0007554168,0.001351181,0.0007505089,0.0009236104,0.0005661133,0.0007079949,0.00062639],"category_scores_gemma":[0.002342661,0.000172838,0.0008979976,0.0007303572,0.0004314622,0.0002529911,0.0005052603,0.000400126,0.0004120625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009318313,"about_ca_system_score_gemma":0.0009172741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01203477,"about_ca_topic_score_gemma":0.01265156,"domain_scores_codex":[0.9995509,0.00009666207,0.00003516384,0.0001687177,0.00007444014,0.00007408072],"domain_scores_gemma":[0.9991797,0.0002565211,0.0001636796,0.00009064082,0.0002209619,0.00008854333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005663669,0.0007449982,0.4884065,0.0004721014,0.001511374,0.0005511497,0.001405619,0.1624727,0.09543838,0.0006919245,0.0039042,0.2387374],"study_design_scores_gemma":[0.0001532888,0.0008606751,0.3655799,0.00008203565,0.0006009403,0.0006067849,0.001045854,0.5991513,0.02712986,0.002670753,0.001909402,0.0002091626],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9531205,0.0005170598,0.04471087,0.0001378307,0.00002297311,0.0001375685,0.0003744766,0.0003020981,0.0006767811],"genre_scores_gemma":[0.9791899,0.00006944944,0.01972895,0.00002052199,0.0000112589,0.00005176271,0.0006046119,0.00003592052,0.0002877573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01203477,"threshold_uncertainty_score":0.02392948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383765387764116,"score_gpt":0.2442390162938114,"score_spread":0.2304013624161702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}