{"id":"W4407240950","doi":"10.1016/j.ejcskn.2025.100284","title":"Prognostic and predictive importance of body mass index and type 2 diabetes in the European Organisation for Research and Treatment of Cancer 1325/KEYNOTE-054 phase III trial of pembrolizumab versus placebo in resected high-risk stage III melanoma","year":2025,"lang":"en","type":"article","venue":"EJC Skin Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Merck Sharp and Dohme","keywords":"Pembrolizumab; Medicine; Placebo; Internal medicine; Type 2 diabetes; Cancer; Oncology; Body mass index; Index (typography); Diabetes mellitus; Alternative medicine; Pathology; Endocrinology; Immunotherapy; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005548704,0.0008292996,0.001332092,0.0002532124,0.000191489,0.000833803,0.0005289899,0.0009036487,0.00166425],"category_scores_gemma":[0.003723056,0.0004369298,0.001701651,0.0002977503,0.0005472972,0.0005121739,0.0003402442,0.001302781,0.0001143924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000525013,"about_ca_system_score_gemma":0.0006834672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007636444,"about_ca_topic_score_gemma":0.001780205,"domain_scores_codex":[0.9982503,0.00133827,0.00007093155,0.0001454655,0.00009147982,0.0001035313],"domain_scores_gemma":[0.9979177,0.0008763248,0.0006633043,0.000155048,0.00006054916,0.000327076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.913347,0.002148541,0.05234418,0.0005334686,0.003474873,0.00005732194,0.000059838,0.001646379,0.004796042,0.0001285957,0.000976664,0.02048711],"study_design_scores_gemma":[0.4300806,0.1623572,0.379144,0.0002187315,0.01212887,0.0003074478,0.0001094442,0.009025108,0.00291813,0.000606267,0.002994759,0.0001095446],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952446,0.003338645,0.0001896461,0.0002588819,0.00009487328,0.0001322348,0.0002569256,0.00001060168,0.0004736233],"genre_scores_gemma":[0.9978918,0.0005709357,0.0003046309,0.0001808162,0.0001091022,0.0001185764,0.0003472366,0.000004046035,0.00047281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005548704,"threshold_uncertainty_score":0.02934468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03411272885735226,"score_gpt":0.3654552700043474,"score_spread":0.3313425411469951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}