{"id":"W4407241720","doi":"10.1097/meg.0000000000002922","title":"Directionality of endoscopic and histologic healing in ulcerative colitis: a prospective pilot study","year":2025,"lang":"en","type":"article","venue":"European Journal of Gastroenterology & Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; St. Paul's Hospital; Western University","funders":"UCB Pharma; Genentech; Teva Pharmaceutical Industries; Mylan; Celgene; Biogen; Gilead Sciences; Celltrion; ActoGeniX; Sanofi; Bristol-Myers Squibb; AstraZeneca; Takeda Oncology; Tillotts Pharma; Amgen; Pfizer","keywords":"Medicine; Ulcerative colitis; Vedolizumab; Rectum; Gastroenterology; Internal medicine; Colonoscopy; Histopathology; Prospective cohort study; Descending colon; Inflammatory bowel disease; Surgery; Pathology; Colorectal cancer; Disease; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001941779,0.0005361509,0.0003931963,0.0003916533,0.0005707807,0.0004883975,0.000311255,0.0005493271,0.001751225],"category_scores_gemma":[0.002507,0.0003924056,0.000391124,0.0003173575,0.0005268269,0.0005345866,0.0004732729,0.0006891714,0.0004803428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002038339,"about_ca_system_score_gemma":0.0003415816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006267187,"about_ca_topic_score_gemma":0.0006837408,"domain_scores_codex":[0.9991711,0.0004117332,0.00005381458,0.0001675283,0.0001024732,0.00009341049],"domain_scores_gemma":[0.997403,0.0005651434,0.0008243096,0.0002913942,0.0002260162,0.0006900671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01522243,0.003552783,0.9702864,0.00004094252,0.0001127868,0.0004519291,0.00031816,0.00005092838,0.00548885,0.00002023503,0.00008477454,0.004369825],"study_design_scores_gemma":[0.0007254688,0.03519998,0.9614583,0.000007019552,0.00006947295,0.001315919,0.0002422092,0.0001685523,0.000489452,0.00001611892,0.0002947412,0.00001276807],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996163,0.00007051189,0.00006601088,0.00000729977,0.000003383506,0.00004631866,0.00004558816,0.000002193591,0.0001424063],"genre_scores_gemma":[0.9994344,0.00004306226,0.0001682317,0.00001780409,0.0000134433,0.00003801961,0.0001046045,0.000001535713,0.0001788512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001941779,"threshold_uncertainty_score":0.01026928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103640883581207,"score_gpt":0.2524960939369603,"score_spread":0.2414596851011482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}