{"id":"W4407249734","doi":"10.20517/cdr.2024.164","title":"Metabolic crossroads: unravelling immune cell dynamics in gastrointestinal cancer drug resistance","year":2025,"lang":"en","type":"review","venue":"Cancer Drug Resistance","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Immune system; Tumor microenvironment; Cancer cell; Biology; Cancer research; Cancer; Metabolic pathway; Immunology; Metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004480808,0.0002675815,0.0004032512,0.0006707326,0.0002659388,0.001280299,0.0003533537,0.0006795297,0.001590664],"category_scores_gemma":[0.0006041071,0.0002411047,0.0003091741,0.0005721317,0.0005911162,0.001861655,0.0006940756,0.001372458,0.0003270803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009120326,"about_ca_system_score_gemma":0.0005514049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001285603,"about_ca_topic_score_gemma":0.001671119,"domain_scores_codex":[0.9998667,0.00003014388,0.000005978176,0.00003410378,0.00003337527,0.00002972283],"domain_scores_gemma":[0.9997854,0.00004911267,0.00006258256,0.00001222807,0.00004123658,0.00004949041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001231968,0.0002273498,0.05892602,0.003357764,0.0002943407,0.001178756,0.001328253,0.01051131,0.387046,0.04729298,0.0266404,0.4619649],"study_design_scores_gemma":[0.0001606068,0.00117354,0.2255972,0.001781466,0.0004896112,0.003762514,0.004087266,0.08822561,0.1198776,0.09182244,0.462804,0.0002182095],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.4839368,0.4165407,0.0559545,0.02155954,0.001333877,0.0001014955,0.001400772,0.0008935232,0.01827886],"genre_scores_gemma":[0.8798924,0.0998975,0.01238134,0.002447629,0.0006716661,0.00008010532,0.0004660453,0.0001031442,0.004060229],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001590664,"threshold_uncertainty_score":0.006617248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049331986257421,"score_gpt":0.2897326410551759,"score_spread":0.2792393211926016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}