{"id":"W4407257284","doi":"10.7554/elife.99373.2","title":"Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"Daiichi Sankyo Europe; Moonshot Research and Development Program; School of Medicine, New York University; National Institute of General Medical Sciences; Japan Society for the Promotion of Science; Wellcome Trust; National Cancer Institute; Japan Science and Technology Agency; Daiichi Sankyo Foundation of Life Science; National Institutes of Health; Biotechnology and Biological Sciences Research Council; LEO Fondet; Uehara Memorial Foundation","keywords":"Cell biology; Chemokine receptor; Endosome; G protein-coupled receptor; CCR1; Chemotaxis; C-C chemokine receptor type 7; CCL21; Biology; C-C chemokine receptor type 6; Signal transduction; Receptor; Chemistry; Chemokine; Biochemistry; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001494055,0.0002847315,0.0002368481,0.0002762174,0.000267336,0.0005427268,0.0001548429,0.0004638859,0.001605945],"category_scores_gemma":[0.0001302603,0.0001438796,0.0002356502,0.0001302545,0.0002910288,0.0004396398,0.000449992,0.0005516065,0.001260877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005387363,"about_ca_system_score_gemma":0.0002296538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005035414,"about_ca_topic_score_gemma":0.0005539926,"domain_scores_codex":[0.9998564,0.00001617777,0.000005322493,0.00002865882,0.00003783913,0.00005561843],"domain_scores_gemma":[0.9999202,0.000007966376,0.0000191558,0.000008831736,0.0000204184,0.00002337212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000151811,0.000008281799,0.0003280181,0.00004416864,0.000004398388,0.0001318576,0.00002164533,0.00009050363,0.9952031,0.002146505,0.0002304299,0.001639193],"study_design_scores_gemma":[0.00004006827,0.00008406815,0.01654093,0.00001915016,0.00001141591,0.0004522623,0.0001277566,0.003353003,0.9676502,0.001309894,0.01039917,0.00001207379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684116,0.005488971,0.01403646,0.000602268,0.0001101508,0.00004952222,0.0009050865,0.000230129,0.01016582],"genre_scores_gemma":[0.9859791,0.00164395,0.004469191,0.0001066793,0.00002615124,0.00002998094,0.0007985877,0.00006933074,0.006876993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001605945,"threshold_uncertainty_score":0.005372465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641026564224464,"score_gpt":0.252572163661834,"score_spread":0.2361618980195894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}