{"id":"W4407260439","doi":"10.1158/2159-8290.cd-24-1662","title":"Knudson’s “Two-Hit” Hypothesis and Cancer Predisposition: A Bit More Complicated but Still Going Strong","year":2025,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Epigenome; Wilms' tumor; Genetic predisposition; Cancer; Genetics; Biology; Genome; Cancer research; Bioinformatics; Medicine; Computational biology; DNA methylation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006297196,0.0006750234,0.001772176,0.001123166,0.00121681,0.003002553,0.001452923,0.004825782,0.008312861],"category_scores_gemma":[0.006722008,0.000375894,0.000990732,0.001052313,0.00853944,0.01008821,0.002432353,0.01135285,0.001497242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001326395,"about_ca_system_score_gemma":0.001152024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002146258,"about_ca_topic_score_gemma":0.002089328,"domain_scores_codex":[0.9983211,0.0005701907,0.00009970839,0.0004008586,0.0003919986,0.0002161112],"domain_scores_gemma":[0.9940041,0.00394856,0.0004113096,0.0005846145,0.0005880503,0.000463422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001105465,0.0002391691,0.02292614,0.001820924,0.00147683,0.004247491,0.002781081,0.001392203,0.00902279,0.552109,0.2209927,0.1818862],"study_design_scores_gemma":[0.000123687,0.0002749931,0.01067645,0.000680805,0.0002578144,0.00415166,0.003235901,0.001017129,0.002127608,0.7007251,0.276501,0.0002279261],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.01762048,0.1470769,0.01388649,0.7917658,0.0130938,0.00003353327,0.0003520741,0.0001750111,0.01599584],"genre_scores_gemma":[0.3820624,0.1785281,0.01246202,0.364098,0.03279435,0.0001143797,0.0005309575,0.0002159653,0.02919371],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008312861,"threshold_uncertainty_score":0.0333032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01022137773395179,"score_gpt":0.2685958773710523,"score_spread":0.2583744996371005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}