{"id":"W4407271121","doi":"10.1016/j.euroneuro.2024.12.013","title":"Improvements in functioning and workplace productivity with esketamine nasal spray versus quetiapine extended release in patients with treatment resistant depression: Findings from a 32-week randomised, open-label, rater-blinded phase IIIb study","year":2025,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Instituto de Salud Carlos III; HORIZON EUROPE Framework Programme; European Commission; European Regional Development Fund; Horizon 2020 Framework Programme; National Institutes of Health; Innovative Medicines Initiative; Ministerio de Ciencia e Innovación; National Institute of Mental Health; Missouri Broadcasters Association; Centro de Investigación Biomédica en Red de Salud Mental; Fundación Alicia Koplowitz","keywords":"Quetiapine; Nasal spray; Open label; Medicine; Depression (economics); Treatment-resistant depression; Psychiatry; Clinical psychology; Psychology; Major depressive disorder; Clinical trial; Internal medicine; Cognition; Nasal administration; Pharmacology; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001890218,0.0007856753,0.002081246,0.0002310846,0.0002150659,0.0005985667,0.0005770752,0.0007100333,0.002367993],"category_scores_gemma":[0.002209629,0.0003827928,0.001430609,0.0002509197,0.0005630717,0.0005858805,0.0002052428,0.001464068,0.0003090102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005425311,"about_ca_system_score_gemma":0.0004432882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008810237,"about_ca_topic_score_gemma":0.00231881,"domain_scores_codex":[0.9992236,0.0004600436,0.0000826151,0.00008951021,0.00007970698,0.00006454129],"domain_scores_gemma":[0.998736,0.0004392322,0.0003297433,0.0001092595,0.00008655215,0.0002992639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9174172,0.01092496,0.002517387,0.0008974,0.001953776,0.00006614319,0.000182478,0.0004761785,0.01750728,0.000047329,0.0005121611,0.0474976],"study_design_scores_gemma":[0.6759704,0.2970097,0.0228169,0.00005287522,0.0009633555,0.0001392428,0.00007287176,0.000949171,0.001337131,0.00006827797,0.0005804233,0.00003965238],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972909,0.001628358,0.000179333,0.0001072611,0.0000478765,0.0002604137,0.000212633,0.000022353,0.0002507968],"genre_scores_gemma":[0.9974415,0.001061337,0.0004482788,0.000125957,0.00007509061,0.0002533127,0.0002053941,0.000007425624,0.0003816363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002367993,"threshold_uncertainty_score":0.009996533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02806114353577196,"score_gpt":0.3303215921694569,"score_spread":0.302260448633685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}