{"id":"W4407271121","doi":"10.1016/j.euroneuro.2024.12.013","title":"Improvements in functioning and workplace productivity with esketamine nasal spray versus quetiapine extended release in patients with treatment resistant depression: Findings from a 32-week randomised, open-label, rater-blinded phase IIIb study","year":2025,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Instituto de Salud Carlos III; HORIZON EUROPE Framework Programme; European Commission; European Regional Development Fund; Horizon 2020 Framework Programme; National Institutes of Health; Innovative Medicines Initiative; Ministerio de Ciencia e Innovación; National Institute of Mental Health; Missouri Broadcasters Association; Centro de Investigación Biomédica en Red de Salud Mental; Fundación Alicia Koplowitz","keywords":"Quetiapine; Nasal spray; Open label; Medicine; Depression (economics); Treatment-resistant depression; Psychiatry; Clinical psychology; Psychology; Major depressive disorder; Clinical trial; Internal medicine; Cognition; Nasal administration; Pharmacology; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004619032,0.0006069986,0.0008712293,0.0005088123,0.0001684067,0.00009224216,0.0002620098,0.0000652409,0.00005769149],"category_scores_gemma":[0.0001384044,0.0004301699,0.00003324247,0.0007739465,0.0001375604,0.0003137912,0.0002830613,0.0005178759,0.000008198685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003005153,"about_ca_system_score_gemma":0.0001466912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001350647,"about_ca_topic_score_gemma":0.0001917033,"domain_scores_codex":[0.9953257,0.00145063,0.0006954274,0.001623719,0.000371937,0.0005325862],"domain_scores_gemma":[0.9983804,0.0002968614,0.0002827848,0.0006822145,0.0001157636,0.0002419507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.644112,0.03428878,0.2432646,0.00003422283,0.0005196708,0.002675734,0.0003540406,0.00002087978,0.05779149,5.661287e-7,0.0002528502,0.01668518],"study_design_scores_gemma":[0.4599203,0.01681865,0.5208743,0.0002332985,0.0004453616,0.000003879797,0.00006594814,0.00002944652,0.00112882,9.609984e-7,0.0002661283,0.000212921],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906231,0.0002515178,0.00001480511,0.0004406053,0.0005675469,0.007224499,0.00001825513,0.0001294802,0.0007302493],"genre_scores_gemma":[0.9976543,0.00004673656,0.0003503538,0.0002463368,0.00007502125,0.0004175044,0.0000777597,0.0001239086,0.001008146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2776097,"threshold_uncertainty_score":0.999815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02806114353577196,"score_gpt":0.3303215921694569,"score_spread":0.302260448633685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}