{"id":"W4407274607","doi":"10.1016/j.pcad.2025.02.005","title":"Chronic psychological stress and cardiovascular disease risk: When to use single biomarkers versus allostatic load","year":2025,"lang":"en","type":"letter","venue":"Progress in Cardiovascular Diseases","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; National Health and Medical Research Council","keywords":"Medicine; Allostatic load; Psychological stress; Allostasis; Disease; Internal medicine; Physiology; Clinical psychology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002166206,0.001120994,0.001820946,0.000621398,0.0003022168,0.0007861396,0.001201503,0.0005805684,0.00007979342],"category_scores_gemma":[0.003411851,0.001057743,0.003254502,0.0008413454,0.0008172709,0.0003345009,0.0008691943,0.001239503,0.00004231423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006060743,"about_ca_system_score_gemma":0.0004354027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002425116,"about_ca_topic_score_gemma":0.00002366868,"domain_scores_codex":[0.989284,0.002324051,0.0007338591,0.003447267,0.002768777,0.001442039],"domain_scores_gemma":[0.993991,0.001305253,0.000186077,0.003685119,0.0001583662,0.0006741546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00463535,0.0008148997,0.04675144,0.003234556,0.01444742,0.03370242,0.0001516919,0.002044613,0.000007728266,0.0000126602,0.1138714,0.7803258],"study_design_scores_gemma":[0.006361793,0.0007250148,0.05775878,0.002377896,0.01143032,0.00004437114,0.00004251066,0.00028641,0.000187119,0.0001733008,0.9180127,0.002599779],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.08207029,0.8552845,0.0006522466,0.03881213,0.004165125,0.00803816,0.009759872,0.0009152347,0.0003024898],"genre_scores_gemma":[0.7349871,0.1288394,0.001729112,0.105157,0.01013875,0.01459072,0.001483218,0.001325795,0.001748905],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.8041413,"threshold_uncertainty_score":0.9991873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03917372455250656,"score_gpt":0.2903627418093349,"score_spread":0.2511890172568283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}