{"id":"W4407285547","doi":"10.1093/jcag/gwae059.184","title":"A184 DISCOVERY OF POTENTIAL LGR5 LIGANDS","year":2025,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Computational biology; LGR5; Drug discovery; Biology; Bioinformatics; Cell biology; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007088943,0.00007419672,0.0002842629,0.0001986253,0.00008692554,0.000008610327,0.0002815227,0.000205155,0.00009980589],"category_scores_gemma":[0.0004046764,0.00005781128,0.0002376142,0.0001357481,0.00009652831,0.00008306028,0.00003568086,0.0005175683,0.000001238873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004919832,"about_ca_system_score_gemma":0.0004068528,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001062138,"about_ca_topic_score_gemma":0.03140406,"domain_scores_codex":[0.9988879,0.0001955567,0.0005065062,0.00006215992,0.000128551,0.0002193258],"domain_scores_gemma":[0.9985229,0.0001439948,0.0008506505,0.00009018547,0.0002949067,0.00009734753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006592869,0.0001707345,0.8605514,0.00002759937,0.0008352611,0.000006069066,0.0001057844,0.0005093419,0.08598307,0.0007776117,0.04982451,0.0005493126],"study_design_scores_gemma":[0.007382704,0.0009515827,0.7325223,0.0001438673,0.001252461,0.000100285,0.0002215199,0.0003896898,0.1246212,0.002793952,0.1294638,0.0001566809],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818674,0.00003944668,0.00006506626,0.01485511,0.001881426,0.00006773792,0.00006100615,0.00000158272,0.001161209],"genre_scores_gemma":[0.9960406,0.0000626984,0.00003162556,0.001807078,0.0001105098,0.000001072079,0.000001905838,0.000003981386,0.001940509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1280291,"threshold_uncertainty_score":0.9862703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01996778525459731,"score_gpt":0.3332312521123629,"score_spread":0.3132634668577656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}