{"id":"W4407285547","doi":"10.1093/jcag/gwae059.184","title":"A184 DISCOVERY OF POTENTIAL LGR5 LIGANDS","year":2025,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Computational biology; LGR5; Drug discovery; Biology; Bioinformatics; Cell biology; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131601,0.0004635599,0.0002074443,0.0002292635,0.00008633961,0.0002666593,0.0002057501,0.0002728397,0.001892498],"category_scores_gemma":[0.0001337836,0.00008775043,0.0002453554,0.0001392306,0.00008815972,0.0001720908,0.0002012088,0.0002952843,0.0007443977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002648207,"about_ca_system_score_gemma":0.0001458987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002530927,"about_ca_topic_score_gemma":0.0003220768,"domain_scores_codex":[0.9999261,0.00001252495,0.000006370197,0.00001540539,0.00002466206,0.00001502194],"domain_scores_gemma":[0.9999555,0.00000559413,0.00001230897,0.000003442108,0.000009682638,0.00001345484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001829494,0.00005699308,0.0002111981,0.0001662187,0.00001672048,0.0001365692,0.00001128143,0.000468472,0.9827446,0.0002226504,0.0002173635,0.0155649],"study_design_scores_gemma":[0.0000944144,0.002127567,0.001918943,0.00004490258,0.000061065,0.0007181104,0.00003180355,0.002474115,0.9650594,0.0001116882,0.02734229,0.00001574064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9457366,0.02388498,0.01956821,0.0004974784,0.0001300438,0.0002583805,0.001356157,0.0002128146,0.008355401],"genre_scores_gemma":[0.9540856,0.01173531,0.02279001,0.0003852735,0.00005294392,0.0001562255,0.001988253,0.00002737299,0.008779018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001892498,"threshold_uncertainty_score":0.006331086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01996778525459731,"score_gpt":0.3332312521123629,"score_spread":0.3132634668577656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}