{"id":"W4407285697","doi":"10.1093/jcag/gwae059.220","title":"A220 LONG-TERM EFFECTIVENESS AND SAFETY OF USTEKINUMAB DOSE ESCALATION IN PATIENTS WITH REFRACTORY ULCERATIVE COLITIS: A MULTICENTER RETROSPECTIVE COHORT STUDY","year":2025,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"","keywords":"Ustekinumab; Ulcerative colitis; Medicine; Refractory (planetary science); Retrospective cohort study; Internal medicine; Cohort; Cohort study; Gastroenterology; Disease; Infliximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002586125,0.0004083342,0.0007262767,0.0007083316,0.0004806829,0.000910442,0.0004118114,0.0005037392,0.00112887],"category_scores_gemma":[0.003690948,0.0003420654,0.001060887,0.0009128315,0.0003351893,0.0007929674,0.0005524397,0.0005353711,0.0002575257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000443749,"about_ca_system_score_gemma":0.0004176548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008050692,"about_ca_topic_score_gemma":0.0006596957,"domain_scores_codex":[0.9982638,0.0005746111,0.0002634804,0.0005232578,0.0002091362,0.0001657872],"domain_scores_gemma":[0.9951675,0.0008633154,0.002450122,0.0007721683,0.0003199094,0.0004269643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0027975,0.0002506998,0.9927949,0.00004438715,0.0003912873,0.0001986405,0.0000916702,0.00008525417,0.0004384881,0.0000234421,0.0001299694,0.002753582],"study_design_scores_gemma":[0.000594692,0.004906258,0.9899821,0.00003266052,0.0006440562,0.001390385,0.000279411,0.0007249299,0.0003736293,0.00004535191,0.0009986627,0.00002791342],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989601,0.00044287,0.0001294372,0.00001765298,0.000005212353,0.00004363712,0.0002791946,0.000002656201,0.0001192017],"genre_scores_gemma":[0.9990188,0.0001348363,0.0001433886,0.0000396665,0.00002456751,0.00004553867,0.0005262964,0.000002512349,0.00006438957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002586125,"threshold_uncertainty_score":0.01367688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002027044719922213,"score_gpt":0.209446846535888,"score_spread":0.2074198018159658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}