{"id":"W4407285752","doi":"10.1093/jcag/gwae059.150","title":"A150 THE PARKINSON’S DISEASE-ASSOCIATED MUTATION LRRK2 G2019S INCITES NEUTROPHILIC INFLAMMATION AND INCREASED TISSUE DAMAGE IN A MOUSE MODEL OF INFECTIOUS COLITIS.","year":2025,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"","keywords":"LRRK2; Inflammation; Colitis; Disease; Parkinson's disease; Immunology; Mutation; Medicine; Biology; Pathology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002793007,0.0009946228,0.0006081295,0.0008672849,0.0002989652,0.0004326045,0.0003588926,0.00133586,0.00354958],"category_scores_gemma":[0.0001360292,0.0003757949,0.0008397151,0.0004149893,0.0006440572,0.0004321414,0.0002295551,0.001993109,0.001017873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004166293,"about_ca_system_score_gemma":0.000250387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006510318,"about_ca_topic_score_gemma":0.0008795069,"domain_scores_codex":[0.9993578,0.00007873854,0.00008498213,0.000195096,0.0001573551,0.0001261411],"domain_scores_gemma":[0.9996589,0.00002971889,0.0001382608,0.00003234226,0.00002059025,0.0001202039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007667173,0.0002161662,0.000362939,0.0001211326,0.00002131117,0.0001699276,0.00003191942,0.0001021576,0.9967237,0.0001171604,0.0002713588,0.001095536],"study_design_scores_gemma":[0.0002463876,0.004067485,0.01899099,0.00006887712,0.00009674459,0.001652845,0.0001712511,0.00329779,0.9661203,0.0002915191,0.0049576,0.00003825095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809189,0.002246056,0.005089178,0.0006563679,0.0003788101,0.0001532865,0.006726721,0.0007162258,0.003114306],"genre_scores_gemma":[0.9802001,0.001394625,0.005058933,0.0003662186,0.00004898296,0.000368939,0.00475823,0.0001218879,0.007682115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00354958,"threshold_uncertainty_score":0.0118745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003534444086703346,"score_gpt":0.2022058068782362,"score_spread":0.1986713627915329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}