{"id":"W4407285830","doi":"10.1093/jcag/gwae059.159","title":"A159 SERUM IGG RESPONSE TO THE D0-D1 HINGE PEPTIDE OF COMMENSAL FLAGELLIN PREDICTS THE FUTURE ONSET OF CROHN’S DISEASE IN HEALTHY FIRST-DEGREE RELATIVES","year":2025,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Manitoba; University of Ottawa; Centre Hospitalier Universitaire Sainte-Justine; Children's Hospital of Eastern Ontario; University of Calgary; University of Alberta; Hospital for Sick Children; Université de Montréal; Hôpital Maisonneuve-Rosemont; University of British Columbia; University of Toronto","funders":"University of Toronto; McMaster University; Centre hospitalier universitaire Sainte-Justine; Hebrew University of Jerusalem; University of Ottawa","keywords":"First-degree relatives; Flagellin; Crohn's disease; Immunology; Disease; Medicine; Biology; Genetics; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004894807,0.0004739372,0.0003454588,0.0006679145,0.0004826664,0.000489291,0.000280844,0.0004733485,0.002410851],"category_scores_gemma":[0.002130401,0.0002526262,0.000340644,0.0003667771,0.0002721845,0.0002387932,0.0003370863,0.0005430629,0.0002928542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002765779,"about_ca_system_score_gemma":0.0001545851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003175715,"about_ca_topic_score_gemma":0.002495891,"domain_scores_codex":[0.9996756,0.00008454065,0.00002703239,0.000105742,0.00004023292,0.00006682175],"domain_scores_gemma":[0.9986472,0.0003060669,0.0004560445,0.0001091817,0.0001034288,0.0003780554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001978275,0.00002387139,0.9979507,0.000004574721,0.00002202701,0.000202033,0.00003306694,0.00002107095,0.0009113016,0.000007915158,0.00007785436,0.0005478716],"study_design_scores_gemma":[0.000009866028,0.0001447263,0.9975861,0.000005566762,0.00003100062,0.001368502,0.000105226,0.0002843094,0.0003061312,0.00002044692,0.0001353763,0.000002669778],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995924,0.00009257182,0.00005183205,0.00002345988,0.000005238307,0.00000151986,0.00006703397,0.000003255295,0.0001626177],"genre_scores_gemma":[0.9997934,0.00001835188,0.00004196466,0.00001023027,0.000005136229,8.863532e-7,0.00005225371,7.51405e-7,0.00007698259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003175715,"threshold_uncertainty_score":0.008065104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005880194023684855,"score_gpt":0.2273891322771666,"score_spread":0.2215089382534817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}