{"id":"W4407285925","doi":"10.1093/jcag/gwae059.148","title":"A148 <i>NOD2</i> LIGAND AND PEPTIDOGLYCAN HYDROLASE GENE ABUNDANCES ARE ALTERED IN PRE-CROHN’S DISEASE","year":2025,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Peptidoglycan; Crohn's disease; NOD2; Ligand (biochemistry); Disease; Gene; Hydrolase; Microbiology; Chemistry; Biology; Genetics; Computational biology; Enzyme; Biochemistry; Medicine; Pathology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000158883,0.0002569116,0.000353687,0.0006497184,0.0002839288,0.0004787096,0.0001962034,0.0003674965,0.002177252],"category_scores_gemma":[0.0007321094,0.0001731045,0.0002033632,0.0005396555,0.0002344879,0.0001649418,0.0002442284,0.000268183,0.0002913862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739341,"about_ca_system_score_gemma":0.00008267341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001193112,"about_ca_topic_score_gemma":0.0009929887,"domain_scores_codex":[0.9997975,0.00003530997,0.00002389397,0.00007695054,0.00003136583,0.00003507798],"domain_scores_gemma":[0.9994541,0.0000866929,0.0002405682,0.00003725118,0.00005557422,0.0001258548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001759354,0.00006543122,0.9666127,0.00003337722,0.00005930711,0.0007427238,0.00008853459,0.00003357953,0.02873681,0.00001925016,0.0001480566,0.001700987],"study_design_scores_gemma":[0.00001164856,0.0001652295,0.9974203,0.000003632943,0.00001800762,0.00105522,0.00006665206,0.00006600603,0.0009782062,0.00001234981,0.0002006072,0.000002100666],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999428,0.0001149432,0.00004433132,0.00000944296,0.000002645472,0.000002656064,0.0002586463,0.000004086835,0.0001351727],"genre_scores_gemma":[0.9992908,0.00003711518,0.0001094486,0.00001853308,0.0000049954,0.000005451305,0.0003583083,0.000002873989,0.0001723275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002177252,"threshold_uncertainty_score":0.007283568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003066488824041538,"score_gpt":0.2036126767505151,"score_spread":0.2005461879264736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}