{"id":"W4407295409","doi":"10.3390/ph18020234","title":"Synthesis and Evaluation of 68Ga- and 177Lu-Labeled [diF-Pro14]Bombesin(6−14) Analogs for Detection and Radioligand Therapy of Gastrin-Releasing Peptide Receptor-Expressing Cancer","year":2025,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Terry Fox Research Institute","funders":"Canadian Institutes of Health Research; University of British Columbia; China Scholarship Council","keywords":"Bombesin; Radioligand; Biodistribution; Chemistry; Agonist; In vivo; Gastrin; Radionuclide therapy; Ex vivo; Receptor; Nuclear medicine; In vitro; Cancer research; Medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002067144,0.0004242261,0.0003037375,0.0001642096,0.0001433123,0.0001992762,0.0004643073,0.0005209253,0.00107573],"category_scores_gemma":[0.0001699745,0.0001984236,0.0002747036,0.0001906868,0.0001525494,0.0002652908,0.0001638345,0.0003663056,0.0005144292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003817935,"about_ca_system_score_gemma":0.0002870773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008212443,"about_ca_topic_score_gemma":0.0008010986,"domain_scores_codex":[0.9998801,0.00002819382,0.00001209203,0.00002605153,0.00003161481,0.00002200888],"domain_scores_gemma":[0.9999177,0.000009441778,0.00002333531,0.000008292908,0.00001459677,0.00002661047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001328922,0.00003353798,0.00005768157,0.00005131872,0.000005785724,0.00005042657,0.00001422763,0.0002822998,0.9972037,0.00007905549,0.00003462718,0.002054391],"study_design_scores_gemma":[0.00007335403,0.001167563,0.0006103766,0.000004955863,0.00002962928,0.0003585641,0.00001338786,0.001268376,0.9927244,0.0000199612,0.00371584,0.00001371697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834751,0.00318935,0.01002759,0.0001013723,0.00003755484,0.0002743221,0.0003482235,0.00009863755,0.002447841],"genre_scores_gemma":[0.9642537,0.002150871,0.02789964,0.0001583205,0.00002061427,0.0002424105,0.001046313,0.00004724516,0.00418093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00107573,"threshold_uncertainty_score":0.00359875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08108105548423448,"score_gpt":0.4166066824935075,"score_spread":0.335525627009273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}