{"id":"W4407295409","doi":"10.3390/ph18020234","title":"Synthesis and Evaluation of 68Ga- and 177Lu-Labeled [diF-Pro14]Bombesin(6−14) Analogs for Detection and Radioligand Therapy of Gastrin-Releasing Peptide Receptor-Expressing Cancer","year":2025,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Terry Fox Research Institute","funders":"Canadian Institutes of Health Research; University of British Columbia; China Scholarship Council","keywords":"Bombesin; Radioligand; Biodistribution; Chemistry; Agonist; In vivo; Gastrin; Radionuclide therapy; Ex vivo; Receptor; Nuclear medicine; In vitro; Cancer research; Medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007772561,0.0001480245,0.0004442904,0.0002409227,0.0001044312,0.00002233016,0.00002678449,0.00006480014,0.00007658654],"category_scores_gemma":[0.000426452,0.0001297139,0.00007021041,0.0002507223,0.0002004532,0.00009361656,0.00002095298,0.0001026309,1.782466e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005553162,"about_ca_system_score_gemma":0.00008334865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004029689,"about_ca_topic_score_gemma":0.000008687619,"domain_scores_codex":[0.9987477,0.0001602161,0.0003826501,0.0002820465,0.0002520788,0.0001753192],"domain_scores_gemma":[0.9988624,0.0003995429,0.0001566489,0.0001141138,0.0003544229,0.0001128908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005861886,0.00007677227,0.004593365,0.0003234014,0.0002602047,3.574347e-7,0.0001038619,0.00000934114,0.7915603,0.00002256937,0.00006442988,0.2023992],"study_design_scores_gemma":[0.004297835,0.00009111968,0.009908809,0.001239382,0.001052628,0.000008604778,0.0001477464,0.02282393,0.9596149,0.0001915261,0.0005113145,0.0001122003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909061,0.00666373,0.0008569161,0.0007284048,0.00002782376,0.0005866744,0.00003382557,0.0000186499,0.0001779025],"genre_scores_gemma":[0.9949989,0.003864659,0.0007200555,0.0002123329,0.00004963701,0.00008893255,0.000005653711,0.00001267695,0.00004719649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.202287,"threshold_uncertainty_score":0.528958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08108105548423448,"score_gpt":0.4166066824935075,"score_spread":0.335525627009273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}