{"id":"W4407295445","doi":"10.1016/j.jaci.2024.12.711","title":"The Impact of Itraconazole, a Strong CYP3A4 Inhibitor, on the Pharmacokinetics and Safety of Camlipixant in Healthy Participants","year":2025,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bellus Health (Canada); McMaster University","funders":"","keywords":"Itraconazole; Pharmacokinetics; CYP3A4; Pharmacology; Medicine; Internal medicine; Antifungal; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00262621,0.0001984349,0.0003918598,0.0002001098,0.0002255849,0.0008436273,0.0002204726,0.0006719307,0.002294064],"category_scores_gemma":[0.01034219,0.0001537653,0.001660674,0.0003386842,0.0002537542,0.0005520885,0.0003681484,0.001161602,0.0001185986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005976175,"about_ca_system_score_gemma":0.0005279062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006625842,"about_ca_topic_score_gemma":0.005000118,"domain_scores_codex":[0.9990575,0.0005210965,0.0000519918,0.00008686195,0.00008581388,0.0001967023],"domain_scores_gemma":[0.9958325,0.00255528,0.0007337315,0.0002005719,0.0001906498,0.0004872697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05441461,0.001515608,0.890514,0.0002749437,0.003966475,0.0005737586,0.0003363443,0.002289515,0.001675972,0.001246381,0.00123308,0.04195931],"study_design_scores_gemma":[0.0008701509,0.004396318,0.9865827,0.00005006141,0.002119676,0.0001817878,0.0002662985,0.00356528,0.0003805187,0.0008427227,0.0007179433,0.00002663324],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975419,0.001137503,0.00007204826,0.0003990865,0.00001646862,0.000008527053,0.0002442797,0.000001888234,0.0005783995],"genre_scores_gemma":[0.9994859,0.0001722361,0.00003709078,0.00006633083,0.00001393608,0.000003693813,0.0001032429,0.000001030339,0.0001165607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006625842,"threshold_uncertainty_score":0.0138889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2669688201824777,"score_gpt":0.4965066588271171,"score_spread":0.2295378386446394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}