{"id":"W4407302984","doi":"10.1021/jacs.4c14102","title":"Streamlining Sulfated Oligosaccharide and Glycan Synthesis with Engineered Mutant 6-SulfoGlcNAcases","year":2025,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Glycomics Network; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Chemistry; Glycan; Oligosaccharide; Mutant; Sulfation; Biochemistry; Glycoprotein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839969,0.000382668,0.0001765487,0.0001107841,0.00007165956,0.0002881451,0.0002262468,0.0001939581,0.0003437164],"category_scores_gemma":[0.0001508029,0.0001219409,0.0001796146,0.0001601854,0.000214481,0.0001579922,0.00022264,0.000463233,0.0001905503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003595256,"about_ca_system_score_gemma":0.0003162982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009904291,"about_ca_topic_score_gemma":0.001381788,"domain_scores_codex":[0.9998479,0.00002461862,0.00002119502,0.00002386457,0.00005158652,0.00003071937],"domain_scores_gemma":[0.9998906,0.0000151939,0.00004149443,0.0000180952,0.00001221968,0.00002233309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003070379,0.00001703169,0.00009630573,0.0000143969,0.000003636391,0.00001623715,0.000007408898,0.0002190528,0.9985756,0.0001401146,0.00002115082,0.0008582728],"study_design_scores_gemma":[0.000002952374,0.00005495852,0.000173253,7.474229e-7,0.000003378344,0.00004367045,0.000004588929,0.00084986,0.9980179,0.00001908669,0.0008277168,0.000001948765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814594,0.000391321,0.01669533,0.00008640935,0.00004701581,0.00004993041,0.0002300587,0.0001371124,0.0009033705],"genre_scores_gemma":[0.9734624,0.0005176968,0.02347695,0.00003565219,0.000007278123,0.00002467903,0.0004137238,0.00004766816,0.002013862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009904291,"threshold_uncertainty_score":0.002608538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006489430468069293,"score_gpt":0.2173793002877616,"score_spread":0.2108898698196923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}