{"id":"W4407313924","doi":"10.1016/s2352-3026(24)00376-4","title":"Long-term efficacy and safety of luspatercept for the treatment of anaemia in patients with transfusion-dependent β-thalassaemia (BELIEVE): final results from a phase 3 randomised trial","year":2025,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"Acceleron; Bristol-Myers Squibb","keywords":"Medicine; Anemia; Term (time); Blood transfusion; Thalassemia; Pediatrics; Intensive care medicine; Randomized controlled trial; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015424,0.001192378,0.002336022,0.0002240463,0.0003582634,0.001408176,0.0008924523,0.001921028,0.005364016],"category_scores_gemma":[0.00180012,0.0005579787,0.003020563,0.0003269107,0.001036696,0.001246199,0.000352606,0.004424787,0.0009715168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007980635,"about_ca_system_score_gemma":0.000593996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009224816,"about_ca_topic_score_gemma":0.002171512,"domain_scores_codex":[0.999429,0.0002801396,0.00003751441,0.0000891345,0.0000553794,0.000108671],"domain_scores_gemma":[0.9988436,0.0004395997,0.0002775181,0.00009048176,0.00005852173,0.0002903792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9642351,0.002097822,0.0009754141,0.001098635,0.003242573,0.00008674692,0.00007968442,0.0004224795,0.003051543,0.0001407897,0.001510633,0.0230585],"study_design_scores_gemma":[0.9423002,0.04924693,0.004909981,0.00008491961,0.001501412,0.0001118162,0.00003697399,0.0003473014,0.0003552862,0.000216988,0.0008577486,0.0000304499],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747917,0.01853218,0.0006096664,0.001447603,0.0005983937,0.0007036155,0.001006249,0.0001089004,0.002201628],"genre_scores_gemma":[0.9889142,0.004274278,0.0007453056,0.00145977,0.0004105667,0.0006944903,0.001177628,0.00002173885,0.002301936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005364016,"threshold_uncertainty_score":0.01794446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966854971311297,"score_gpt":0.2962753664823692,"score_spread":0.2766068167692562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}