{"id":"W4407315970","doi":"10.1371/journal.pone.0305511","title":"PCK1 and SLC22A2 gene variants associated with response to metformin treatment in type 2 diabetes","year":2025,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Faculté de médecine et des sciences de la santé, Université de Sherbrooke; Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Diabète Québec","keywords":"Metformin; Pharmacogenetics; Type 2 diabetes; Medicine; Odds ratio; Genotyping; Linkage disequilibrium; Candidate gene; Internal medicine; Confidence interval; Allele; Diabetes mellitus; Genotype; Bioinformatics; Genetics; Gene; Biology; Haplotype; Endocrinology; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00049399,0.0003873454,0.0004104686,0.0008356025,0.0003478288,0.0004926426,0.000276035,0.0005333361,0.00207274],"category_scores_gemma":[0.001854734,0.0001571306,0.0005701187,0.001243276,0.0002358692,0.0002045364,0.0002578483,0.0005054645,0.0002206268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001745374,"about_ca_system_score_gemma":0.0001388675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00231614,"about_ca_topic_score_gemma":0.001899751,"domain_scores_codex":[0.9995331,0.0001484904,0.0000629,0.0001388603,0.00006989692,0.00004670904],"domain_scores_gemma":[0.9986965,0.000405087,0.0005790204,0.00007305127,0.00007687943,0.0001693608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009500868,0.0000648177,0.993872,0.00002783678,0.0001757026,0.0003749478,0.0000899872,0.00008434913,0.001666344,0.00002059995,0.00007655403,0.002596631],"study_design_scores_gemma":[0.00001539288,0.00009864617,0.9986565,0.000006719714,0.00006731995,0.0005775283,0.00004576526,0.0002490229,0.0001323372,0.00002569609,0.0001214628,0.000003736668],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991715,0.0003833754,0.0000773466,0.00003742682,0.000007236089,0.000005398023,0.0001428807,0.000002688175,0.0001720943],"genre_scores_gemma":[0.9995145,0.00007861469,0.0001044639,0.00001976715,0.00001119258,0.000005737782,0.0001183899,0.000002493911,0.0001448495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00231614,"threshold_uncertainty_score":0.006934047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02759821926742782,"score_gpt":0.2432349791156428,"score_spread":0.215636759848215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}