{"id":"W4407315979","doi":"10.1021/acs.chemrestox.4c00460","title":"Novel Organophosphate Ester Tris(2,4-di-<i>tert</i>-butylphenyl)phosphate Alters Lipid Metabolism: Insights from Lipidomic Analysis and mRNA Expression","year":2025,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada","funders":"National Natural Science Foundation of China","keywords":"Organophosphate; Chemistry; Phosphate; Tris; Messenger RNA; Metabolism; Lipid metabolism; Biochemistry; Biology; Pesticide; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005097642,0.0003770954,0.0007232024,0.0006738237,0.0001421765,0.00009120942,0.0006819377,0.0008394747,0.0000979413],"category_scores_gemma":[0.0008477571,0.0003378138,0.0001715685,0.001577582,0.0005973515,0.00002628923,0.001041397,0.0008687797,0.00001520649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001468648,"about_ca_system_score_gemma":0.0002529487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001149984,"about_ca_topic_score_gemma":0.0000483005,"domain_scores_codex":[0.9964626,0.0004009934,0.0005981109,0.001273229,0.0003654182,0.0008996203],"domain_scores_gemma":[0.9982303,0.0003550819,0.0001401864,0.0007138529,0.0002019235,0.0003586808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001012653,0.0003011612,0.004778535,0.00002523141,0.0004231254,0.00001003438,0.00008474181,0.0000313055,0.9911659,0.00003358679,0.0008110192,0.001322709],"study_design_scores_gemma":[0.002446441,0.0000855722,0.00258236,0.00004740826,0.00008795964,0.000002235143,0.00005901175,0.0002519302,0.9836392,0.0002922044,0.01020387,0.0003017474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940194,0.003439972,0.0007205551,0.0007305874,0.0003392977,0.0004403226,0.00003962028,0.00002682921,0.000243436],"genre_scores_gemma":[0.9964287,0.0009978703,0.0009015672,0.000745918,0.000286183,0.0001403442,0.0001799516,0.0000407572,0.0002787364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009392845,"threshold_uncertainty_score":0.9999074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02097487735996442,"score_gpt":0.3195985587672984,"score_spread":0.298623681407334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}