{"id":"W4407317707","doi":"10.1016/j.jtct.2025.02.005","title":"Improvement in Skin Fibrosis and Lung Function with Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis","year":2025,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Public Health; University of Ottawa; Jewish General Hospital; McGill University; Ottawa Hospital","funders":"Canadian Arthritis Network; Fonds de Recherche du Québec - Santé; Actelion Pharmaceuticals; Canadian Institutes of Health Research; Pfizer; Scleroderma Society of Ontario; Jewish General Hospital; Scleroderma Foundation","keywords":"Medicine; Hematopoietic stem cell transplantation; Transplantation; Lung; Stem cell; Haematopoiesis; Pulmonary fibrosis; Scleroderma (fungus); Fibrosis; Lung transplantation; Lung function; Multiple sclerosis; Pathology; Immunology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003359705,0.0001584093,0.0003300951,0.0002454195,0.0001790973,0.0001250568,0.0001240575,0.0002286496,0.00120932],"category_scores_gemma":[0.0003100972,0.00004901444,0.0002256,0.0001885226,0.000341568,0.0001801923,0.0001041252,0.0004258304,0.0001203348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008148016,"about_ca_system_score_gemma":0.0001380199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002401615,"about_ca_topic_score_gemma":0.0004183462,"domain_scores_codex":[0.9999098,0.00003780133,0.00000810972,0.000007775856,0.00002221956,0.00001432093],"domain_scores_gemma":[0.9998999,0.00003980654,0.00001334352,0.00001210425,0.000008633969,0.00002627108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.06221763,0.008558155,0.0491411,0.000774454,0.0003103325,0.007949976,0.0003265285,0.002193789,0.5182929,0.0008128951,0.001431901,0.3479903],"study_design_scores_gemma":[0.006174521,0.1134548,0.5865059,0.0001145909,0.0008436905,0.02475622,0.0005103965,0.0061291,0.2534018,0.001516842,0.006540038,0.00005203359],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958485,0.001996377,0.0004306788,0.00009134636,0.00002278258,0.00001826149,0.00002173062,0.00002950859,0.001540729],"genre_scores_gemma":[0.9989742,0.0004356275,0.0001644903,0.00002821129,0.00002766656,0.000007371464,0.00002781725,0.000001505589,0.0003330857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00120932,"threshold_uncertainty_score":0.004045546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008796583721531744,"score_gpt":0.2098635964201236,"score_spread":0.2010670126985919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}