{"id":"W4407317707","doi":"10.1016/j.jtct.2025.02.005","title":"Improvement in Skin Fibrosis and Lung Function with Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis","year":2025,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Public Health; University of Ottawa; Jewish General Hospital; McGill University; Ottawa Hospital","funders":"Canadian Arthritis Network; Fonds de Recherche du Québec - Santé; Actelion Pharmaceuticals; Canadian Institutes of Health Research; Pfizer; Scleroderma Society of Ontario; Jewish General Hospital; Scleroderma Foundation","keywords":"Medicine; Hematopoietic stem cell transplantation; Transplantation; Lung; Stem cell; Haematopoiesis; Pulmonary fibrosis; Scleroderma (fungus); Fibrosis; Lung transplantation; Lung function; Multiple sclerosis; Pathology; Immunology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001697631,0.0001813513,0.0003002538,0.0002710689,0.00005864978,0.00002925011,0.00003072532,0.0001367943,0.00001231483],"category_scores_gemma":[3.083549e-7,0.0001409143,0.00003889961,0.0002843662,0.00004019308,0.0000795092,0.000001864069,0.0001194416,0.000001224221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005042091,"about_ca_system_score_gemma":0.00004731223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001585337,"about_ca_topic_score_gemma":0.00004581953,"domain_scores_codex":[0.9988849,0.00008431107,0.0003806847,0.0003190791,0.0001545233,0.0001764617],"domain_scores_gemma":[0.9996781,0.00005307279,0.00006997847,0.0001100964,0.00002526074,0.00006343688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005210062,0.0003685735,0.0885806,0.005362319,0.0001392374,0.00008339317,0.00966794,0.0001647943,0.846744,0.0002284832,0.00001212621,0.04343845],"study_design_scores_gemma":[0.02790219,0.0009731169,0.6177088,0.01319726,0.0007057617,0.0001604452,0.006299609,0.001819156,0.3307179,0.00004117095,0.00001276304,0.000461856],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776225,0.01839776,0.002658,0.000102486,0.00006912213,0.0008590827,0.00001131769,0.00004127993,0.0002384318],"genre_scores_gemma":[0.9650748,0.03442681,0.0000304148,0.000157815,0.00000885223,0.00009924763,0.00007043433,0.00001487602,0.000116759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5291282,"threshold_uncertainty_score":0.5746318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008796583721531744,"score_gpt":0.2098635964201236,"score_spread":0.2010670126985919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}