{"id":"W4407317724","doi":"10.3389/fonc.2025.1491314","title":"Meta-analysis to evaluate the comparative effectiveness of enzalutamide and abiraterone acetate for first-line treatment of metastatic castration-resistant prostate cancer in real-world settings","year":2025,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Astellas Pharma; Astellas Pharma US; Pfizer","keywords":"Enzalutamide; Medicine; Abiraterone acetate; Prostate cancer; Oncology; Meta-analysis; Discontinuation; Internal medicine; Adverse effect; Hazard ratio; Androgen deprivation therapy; Prostate-specific antigen; Androgen receptor; Cancer; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03216663,0.004536616,0.02222247,0.009194572,0.0007081092,0.005095811,0.002854679,0.003460548,0.004459159],"category_scores_gemma":[0.06293216,0.00178078,0.07873579,0.007064518,0.0007934387,0.002491567,0.001852182,0.00340347,0.0004600973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004506544,"about_ca_system_score_gemma":0.003418619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007696248,"about_ca_topic_score_gemma":0.009440713,"domain_scores_codex":[0.9738192,0.01823238,0.004044435,0.001804847,0.001624043,0.0004750899],"domain_scores_gemma":[0.964505,0.02834222,0.003941408,0.001199392,0.001633056,0.0003788663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002704042,0.00002156057,0.001883354,0.05021846,0.9402913,0.00007653121,0.000023299,0.001168722,0.0001039455,0.000123985,0.00025609,0.003128755],"study_design_scores_gemma":[0.0008039354,0.0002034626,0.001571089,0.003745329,0.9921869,0.00005064434,0.00001838812,0.0004736635,0.00007450195,0.0002757036,0.0005804147,0.00001592364],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01741497,0.9736617,0.003370873,0.0007096974,0.0006912514,0.001104914,0.001831897,0.0001259525,0.001088682],"genre_scores_gemma":[0.6196988,0.3586878,0.01023534,0.002328181,0.0006921111,0.003862101,0.003196502,0.0001252518,0.001173977],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03216663,"threshold_uncertainty_score":0.1701154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2021586447552913,"score_gpt":0.4953345296009628,"score_spread":0.2931758848456715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}