{"id":"W4407317759","doi":"10.1038/s41591-025-03494-0","title":"Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia","year":2025,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute on Aging","keywords":"Dementia; Alzheimer's disease; Disease; Mutation; Gerontology; Medicine; Genetics; Psychology; Biology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743769,0.0002367712,0.0007026023,0.0008905604,0.00008249282,0.000007799407,0.0001161711,0.0002001004,0.0008226215],"category_scores_gemma":[0.0004838114,0.0001654029,0.0002216541,0.002602176,0.0002346115,0.00006714307,0.00004675937,0.0004321902,0.000005660719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006351079,"about_ca_system_score_gemma":0.0003337566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006354079,"about_ca_topic_score_gemma":0.0000873275,"domain_scores_codex":[0.9979595,0.0001023631,0.0004182165,0.0004559174,0.0007700675,0.0002939559],"domain_scores_gemma":[0.9982746,0.0001399479,0.0001433693,0.0005049129,0.0005199392,0.0004171866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005377164,0.0008054762,0.7861325,0.0001366005,0.1963699,0.001075678,0.0002136095,0.00001040984,0.001638238,0.0001950903,0.002475962,0.005569384],"study_design_scores_gemma":[0.004688003,0.0002119383,0.9125801,0.0003783422,0.07863704,0.000001565061,0.00007852133,0.001155981,0.001629853,0.0002181176,0.0003164889,0.0001040213],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8938228,0.1008874,0.0003131554,0.002598002,0.0001707696,0.001192667,0.0003023566,0.00006240498,0.0006503777],"genre_scores_gemma":[0.9969866,0.0001141342,0.0002900856,0.0003189488,0.000108238,0.0001007032,0.00200838,0.0000162231,0.00005672773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1264476,"threshold_uncertainty_score":0.9007129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878145681622845,"score_gpt":0.3463023872636532,"score_spread":0.3275209304474248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}