{"id":"W4407320100","doi":"10.1021/acs.est.4c09458","title":"Number of Carbons Is a Critical Parameter for Accumulation of Per- and Polyfluoroalkyl Substances in the Human Brain","year":2025,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"PolicyWise for Children & Families","funders":"National Health and Medical Research Council; Minderoo Foundation; Australian Research Council; University of Queensland; Queensland Health","keywords":"Human brain; Environmental chemistry; Chemistry; Environmental science; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003436441,0.000454133,0.0002746617,0.0007721279,0.0002974728,0.0004669346,0.000171088,0.0005891243,0.001687306],"category_scores_gemma":[0.000790691,0.0002191633,0.000207072,0.0003814699,0.0003451739,0.0004811399,0.0002086918,0.0002995549,0.000658549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002768937,"about_ca_system_score_gemma":0.000339376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002115454,"about_ca_topic_score_gemma":0.002057817,"domain_scores_codex":[0.9996222,0.00005387231,0.00003258574,0.0001217154,0.000122102,0.00004746527],"domain_scores_gemma":[0.9996388,0.00009469769,0.0001069822,0.00002036055,0.0001113988,0.00002764515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000603768,0.00006525672,0.04318263,0.0002711435,0.000113921,0.0004584912,0.0001757074,0.0004009152,0.9274161,0.000314598,0.0004179872,0.0265795],"study_design_scores_gemma":[0.000009418685,0.0008996205,0.2640902,0.000100402,0.0001803871,0.00327749,0.0005940512,0.002391803,0.7198198,0.001364824,0.007203248,0.00006876183],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641199,0.01798735,0.01190856,0.0003194503,0.00008249935,0.00007222273,0.001135311,0.0001108674,0.004263906],"genre_scores_gemma":[0.9814391,0.006529269,0.008871819,0.0001347187,0.0000307124,0.0001046918,0.0007867138,0.00003080478,0.002072137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002115454,"threshold_uncertainty_score":0.005644619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02747247744563983,"score_gpt":0.3700709327577317,"score_spread":0.3425984553120919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}