{"id":"W4407321878","doi":"10.3390/cells14040250","title":"Peripheral Immune Profiles in Individuals at Genetic Risk of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North","funders":"Max-Planck-Institut für Bildungsforschung; Bundesministerium für Bildung und Forschung; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; Deutsche Forschungsgemeinschaft","keywords":"Immune system; Amyotrophic lateral sclerosis; CD8; Genome-wide association study; Immunology; Disease; Genetic association; Biology; T cell; Genetic predisposition; Medicine; Single-nucleotide polymorphism; Genetics; Genotype; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000224614,0.0002040613,0.0004537476,0.0002286713,0.00008263198,0.00002651328,0.0001566763,0.0001134718,0.0004124376],"category_scores_gemma":[0.0000590589,0.0001676637,0.0001079666,0.0003500985,0.0002937157,0.00006479395,0.0003118585,0.0002699577,0.00002493699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001097546,"about_ca_system_score_gemma":0.0001267858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000359418,"about_ca_topic_score_gemma":0.00001431771,"domain_scores_codex":[0.9981907,0.0001732061,0.000480304,0.0003922339,0.0003496481,0.00041389],"domain_scores_gemma":[0.9991079,0.0000716191,0.0001042422,0.0004208344,0.00007599077,0.000219446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003181118,0.000186634,0.858296,0.000192284,0.0001707475,0.00002488747,0.0002742443,0.00007727232,0.1351806,0.00002034801,0.0004193285,0.004839583],"study_design_scores_gemma":[0.001989102,0.0001313184,0.9767394,0.0004072166,0.0002044283,0.000001523713,0.00001469105,0.000612298,0.01940834,0.0001551806,0.0002021778,0.0001343041],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907535,0.007364902,0.000005197945,0.0006635917,0.00008444508,0.0007925017,0.00006226771,0.00002526668,0.0002483],"genre_scores_gemma":[0.9955353,0.002172232,0.0006302641,0.0001218007,0.00004145404,0.00006832281,0.00002123579,0.00002537585,0.001384036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1184434,"threshold_uncertainty_score":0.6837125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239621314691175,"score_gpt":0.2730057820896632,"score_spread":0.2506095689427514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}