{"id":"W4407321878","doi":"10.3390/cells14040250","title":"Peripheral Immune Profiles in Individuals at Genetic Risk of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North","funders":"Max-Planck-Institut für Bildungsforschung; Bundesministerium für Bildung und Forschung; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; Deutsche Forschungsgemeinschaft","keywords":"Immune system; Amyotrophic lateral sclerosis; CD8; Genome-wide association study; Immunology; Disease; Genetic association; Biology; T cell; Genetic predisposition; Medicine; Single-nucleotide polymorphism; Genetics; Genotype; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003435667,0.0003171182,0.0003554784,0.000785688,0.00036302,0.0004025698,0.0001622935,0.0005174981,0.001340842],"category_scores_gemma":[0.001232106,0.0001984592,0.000203951,0.0005498079,0.0002219564,0.0002733553,0.0002801119,0.0003875856,0.00019502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150516,"about_ca_system_score_gemma":0.00007876769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001323089,"about_ca_topic_score_gemma":0.001100511,"domain_scores_codex":[0.9998016,0.00005131564,0.00001935281,0.00007144611,0.00002444083,0.00003191373],"domain_scores_gemma":[0.9995983,0.00009212444,0.0001443545,0.00003994789,0.00004078317,0.00008461905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007027913,0.00006327804,0.992402,0.0000129727,0.00006594198,0.0003029893,0.0001805836,0.00004845703,0.003161644,0.00002983336,0.00007987118,0.002949686],"study_design_scores_gemma":[0.000009040798,0.0001353514,0.9990075,0.00000273576,0.00002629298,0.0003979881,0.00007493144,0.00009805699,0.0001140888,0.00005714233,0.00007362453,0.000003282032],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996061,0.0001129878,0.00004909717,0.00001220377,0.000002942651,0.000002034128,0.00005410426,0.000002271755,0.000158201],"genre_scores_gemma":[0.9995614,0.00003908452,0.00009263757,0.00002380028,0.000006704809,0.000004437097,0.0000881479,0.000001305902,0.000182553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001340842,"threshold_uncertainty_score":0.004485548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239621314691175,"score_gpt":0.2730057820896632,"score_spread":0.2506095689427514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}