{"id":"W4407324525","doi":"10.1042/bst20241419","title":"Advances in nanobody multimerization and multispecificity: from <i>in vivo</i> assembly to <i>in vitro</i> production","year":2025,"lang":"en","type":"review","venue":"Biochemical Society Transactions","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Avidity; In vivo; In vitro; Epitope; Computational biology; Antigen; Affinity maturation; Antibody; Chemistry; Biology; Biochemistry; Combinatorial chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006140256,0.0007389347,0.0007287116,0.002052655,0.0001573431,0.0007056012,0.0005770221,0.0007782532,0.001639047],"category_scores_gemma":[0.00041219,0.0003566378,0.0004405259,0.001576189,0.000408968,0.001004487,0.0005379756,0.001297902,0.001163571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005728492,"about_ca_system_score_gemma":0.000739284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005664352,"about_ca_topic_score_gemma":0.0007447735,"domain_scores_codex":[0.9998079,0.00002525264,0.00001950632,0.00003712454,0.00008805207,0.00002209003],"domain_scores_gemma":[0.9998268,0.00007775519,0.00002699008,0.000008332122,0.00004557807,0.00001467805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006207669,0.0001204509,0.0001881869,0.01851057,0.00008988976,0.0001767488,0.00009141371,0.0007338082,0.02880157,0.01078991,0.009762449,0.9306729],"study_design_scores_gemma":[0.0000141945,0.0001873832,0.0007419388,0.001262128,0.00008509239,0.0008770334,0.00004281298,0.0002460213,0.01297153,0.001744006,0.9818025,0.00002534191],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009526747,0.9936562,0.001639142,0.0002529672,0.0001725847,0.00001374983,0.00002318051,0.00002782235,0.003261851],"genre_scores_gemma":[0.003399103,0.9936503,0.001214532,0.0001993365,0.0001119982,0.00001980343,0.00003878593,0.000004902091,0.001361342],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002052655,"threshold_uncertainty_score":0.00548315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02318182832910642,"score_gpt":0.347665979164679,"score_spread":0.3244841508355726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}