{"id":"W4407327645","doi":"10.1136/bmjopen-2024-087922","title":"Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2): study protocol for a phase 2, prospective, multicentre, open-label, multiarm, biomarker-directed, signal-seeking, umbrella, clinical trial for recurrent IDH mutant, grade 2/3 glioma","year":2025,"lang":"en","type":"article","venue":"BMJ Open","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of Manitoba; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Medical Research Future Fund","keywords":"Medicine; Clinical trial; Informed consent; Oncology; Clinical endpoint; Phases of clinical research; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007385204,0.002461924,0.002352594,0.0006201081,0.001676279,0.002524032,0.003262042,0.003870477,0.02430104],"category_scores_gemma":[0.003837467,0.00136234,0.001315925,0.001062923,0.001394833,0.001970489,0.001157909,0.004708956,0.009112393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003276178,"about_ca_system_score_gemma":0.007407693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001803902,"about_ca_topic_score_gemma":0.007694901,"domain_scores_codex":[0.9971927,0.001731523,0.0001352306,0.0003036847,0.0003014021,0.0003354617],"domain_scores_gemma":[0.9976764,0.0001998764,0.0004984026,0.0002541603,0.0001859452,0.001185196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7972094,0.01945738,0.004488966,0.004103697,0.0009151405,0.0006705654,0.0004030764,0.002157516,0.01834522,0.004400253,0.08944961,0.05839909],"study_design_scores_gemma":[0.8250752,0.06692151,0.009756641,0.000607981,0.0004136256,0.0004394946,0.0001341527,0.001458295,0.00322239,0.002457964,0.08941531,0.00009755231],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1670317,0.005153696,0.007756265,0.006747937,0.001489431,0.7239805,0.04473327,0.0009807021,0.04212644],"genre_scores_gemma":[0.1463102,0.002961327,0.01478984,0.008604103,0.0006090209,0.7808892,0.02180188,0.0002145139,0.02381984],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02430104,"threshold_uncertainty_score":0.08129513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2527511022067666,"score_gpt":0.5401112346163096,"score_spread":0.287360132409543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}