{"id":"W4407329289","doi":"10.1097/tp.0000000000005351","title":"All Cloak and No Dagger? Immunosuppression-free Lung Transplantation by Sustained Knockdown of Major Histocompatibility Complex Expression in the Graft","year":2025,"lang":"en","type":"article","venue":"Transplantation","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Immunosuppression; Gene knockdown; Histocompatibility; Transplantation; Immunology; Lung transplantation; Medicine; Major histocompatibility complex; Biology; Surgery; Immune system; Antigen; Human leukocyte antigen; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006186978,0.0003187936,0.0005340931,0.0002527478,0.0003398931,0.001131005,0.0003501975,0.000593939,0.003568204],"category_scores_gemma":[0.0002823238,0.0001750961,0.0003208536,0.0002221135,0.0009004505,0.001000334,0.0004717344,0.001673708,0.0006479878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002917598,"about_ca_system_score_gemma":0.0004525097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002599219,"about_ca_topic_score_gemma":0.000778725,"domain_scores_codex":[0.9997168,0.00004637574,0.00002112572,0.00006391198,0.00006737747,0.00008446266],"domain_scores_gemma":[0.9997657,0.00003089017,0.00006241177,0.00004872007,0.00001559379,0.00007660491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001967792,0.0002929834,0.001517593,0.0003117296,0.00008537107,0.0001872533,0.0000939458,0.000154686,0.9625608,0.003851848,0.001567953,0.02740795],"study_design_scores_gemma":[0.0003006426,0.003301375,0.009483401,0.00009929063,0.000281951,0.0009816948,0.0005120827,0.001280509,0.9402506,0.00264429,0.04081513,0.00004908273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.949181,0.01480852,0.02098919,0.006111884,0.001684325,0.0001317279,0.0006134163,0.0006690443,0.005810837],"genre_scores_gemma":[0.9821338,0.00348311,0.003093664,0.001408984,0.00007268271,0.00007804234,0.00024638,0.00008064046,0.009402644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003568204,"threshold_uncertainty_score":0.01193684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01569386277624516,"score_gpt":0.3250419397818274,"score_spread":0.3093480770055823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}