{"id":"W4407335005","doi":"10.3390/pharmacy13010022","title":"A Physicochemical Stability Study of Pembrolizumab Vial Leftovers: Let Us Stop Pouring Good Money Down the Drain","year":2025,"lang":"en","type":"article","venue":"Pharmacy","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Université Laval","keywords":"Vial; Pembrolizumab; Business; Chemistry; Medicine; Chromatography; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004185615,0.0001445796,0.000169211,0.00002185912,0.0001062022,0.00002041727,0.0003560752,0.0000413993,0.0000516276],"category_scores_gemma":[0.0001874852,0.0001161056,0.0001071521,0.0001327017,0.0001210225,0.000006338739,0.0002072798,0.0001618069,0.000003013771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003205423,"about_ca_system_score_gemma":0.0001333561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001609547,"about_ca_topic_score_gemma":0.00002226562,"domain_scores_codex":[0.9987192,0.000256761,0.0002836363,0.0003827336,0.0001644035,0.0001932216],"domain_scores_gemma":[0.9990898,0.00004212188,0.00008936924,0.0006195062,0.0001080416,0.00005112191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000598256,0.001410981,0.01521194,0.00004956083,0.0001248689,6.548352e-7,0.0005600301,0.00001854461,0.9768596,0.0001660716,0.0003109034,0.004688603],"study_design_scores_gemma":[0.003376692,0.0001034602,0.01051545,0.000006860438,0.00005764188,0.000001220675,0.0006001696,0.0002909827,0.9670473,0.0002553273,0.01758908,0.0001558631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952829,0.000399306,0.0004122482,0.0005575143,0.0000939246,0.0006817465,0.00003322545,0.00001762289,0.002521439],"genre_scores_gemma":[0.9994048,0.00002089919,0.00003438918,0.0002212214,0.00009650193,0.00008533739,0.00002139943,0.000008193628,0.0001072632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01727818,"threshold_uncertainty_score":0.4734651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956039430442048,"score_gpt":0.3128346828025867,"score_spread":0.2932742884981663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}