{"id":"W4407340944","doi":"10.1016/j.jaci.2024.12.970","title":"Responses to Avapritinib in Patients Without Detectable KIT Mutations by ddPCR in Peripheral Blood Highlight Diagnostic Challenges and Opportunities in Indolent Systemic Mastocytosis","year":2025,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Systemic mastocytosis; Peripheral blood; Medicine; Pathology; Internal medicine; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007304553,0.0004872436,0.0007612435,0.0004331,0.0003091543,0.0009082279,0.0003461462,0.0008432303,0.001006774],"category_scores_gemma":[0.001995401,0.0001832198,0.000349346,0.0002451875,0.0004152429,0.0006652736,0.000252105,0.001261183,0.0004215717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004409809,"about_ca_system_score_gemma":0.0002213415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005879662,"about_ca_topic_score_gemma":0.0009964971,"domain_scores_codex":[0.9991673,0.0001735396,0.0001113515,0.0001955155,0.000194293,0.0001579665],"domain_scores_gemma":[0.9988617,0.000654385,0.0001467391,0.0000737397,0.0001197296,0.0001437453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004778256,0.0003353172,0.6295841,0.0003933336,0.0001489771,0.03326911,0.0006638844,0.001396511,0.1922618,0.0005162064,0.004479269,0.1321732],"study_design_scores_gemma":[0.0002258594,0.006423063,0.7107301,0.0002875202,0.0004503247,0.1299001,0.002115991,0.01207979,0.1138098,0.002017725,0.02185828,0.0001012927],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747955,0.00762545,0.004377078,0.003010437,0.0003482214,0.00008633259,0.0004473246,0.0004033923,0.00890632],"genre_scores_gemma":[0.9976761,0.0003899995,0.0007859188,0.0006488482,0.00009904907,0.00001041562,0.0001345296,0.00001405205,0.0002410321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006774,"threshold_uncertainty_score":0.003863037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02395851267831994,"score_gpt":0.2746643472531055,"score_spread":0.2507058345747855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}