{"id":"W4407347962","doi":"10.1038/s41477-025-01924-y","title":"Histone H3 lysine 4 methylation recruits DNA demethylases to enforce gene expression in Arabidopsis","year":2025,"lang":"en","type":"article","venue":"Nature Plants","topic":"Plant Molecular Biology Research","field":"Agricultural and Biological Sciences","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada","funders":"Bill and Melinda Gates Foundation; Howard Hughes Medical Institute","keywords":"H3K4me3; Histone methylation; DNA methylation; Epigenomics; Biology; DNA demethylation; Histone methyltransferase; RNA-Directed DNA Methylation; Cancer epigenetics; Histone; Histone H3; Epigenetics; Methylation; Genetics; Molecular biology; DNA; Gene; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410633,0.0002504144,0.0001742601,0.0001862788,0.0001499642,0.0002503712,0.0002540532,0.0001909344,0.000925023],"category_scores_gemma":[0.00009384571,0.0002624855,0.0002267154,0.0001254198,0.0001918064,0.0001542151,0.0003046325,0.000466433,0.0005365831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006541521,"about_ca_system_score_gemma":0.0002084462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001777828,"about_ca_topic_score_gemma":0.003172259,"domain_scores_codex":[0.9999291,0.000007592587,0.000005035729,0.00001949589,0.00002196133,0.00001692173],"domain_scores_gemma":[0.9999461,0.000008134725,0.0000149436,0.00001087134,0.000005570027,0.00001437516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003051182,0.000002346988,0.0001214218,0.00001702208,0.000002130986,0.00001613364,0.000004501868,0.0000628739,0.9987609,0.00006693479,0.00002394457,0.000891262],"study_design_scores_gemma":[0.0000103105,0.00003635357,0.006031989,0.000003447923,0.000009524199,0.00006583025,0.00001459581,0.0010264,0.9888581,0.0001244444,0.003813778,0.000005234671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815282,0.00334754,0.009577775,0.0001972643,0.00006588913,0.00003040899,0.0006884563,0.0005124056,0.004052093],"genre_scores_gemma":[0.989636,0.0007470908,0.003756078,0.0001360936,0.000007274309,0.00001749659,0.0006037727,0.00008391812,0.005012259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001777828,"threshold_uncertainty_score":0.004746199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02109737590446373,"score_gpt":0.3087885927882599,"score_spread":0.2876912168837962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}