{"id":"W4407348921","doi":"10.1093/eurheartj/ehaf024","title":"Atrial cardiomyocyte-restricted cleavage of gasdermin D promotes atrial arrhythmogenesis","year":2025,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Cancer Institute; National Institutes of Health; European Commission; Cancer Prevention and Research Institute of Texas; National Heart, Lung, and Blood Institute; Norges Idrettshøgskole; Deutsche Forschungsgemeinschaft; National Center for Research Resources; American Heart Association","keywords":"Pyroptosis; Medicine; Inflammasome; Cell biology; Mitochondrial ROS; Atrial fibrillation; Reactive oxygen species; Internal medicine; Inflammation; Oxidative stress; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001946631,0.0002249691,0.0002337905,0.0001306423,0.0001032558,0.0002061617,0.00009517701,0.0002665089,0.001583703],"category_scores_gemma":[0.0001147276,0.00009941147,0.0002851205,0.00007876927,0.000249272,0.0001587196,0.000177133,0.000539004,0.0002887779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001499832,"about_ca_system_score_gemma":0.0001164491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001009744,"about_ca_topic_score_gemma":0.000149863,"domain_scores_codex":[0.9998573,0.00002514744,0.00002438281,0.0000357421,0.00002462248,0.00003269792],"domain_scores_gemma":[0.9998766,0.00001811695,0.00004040336,0.00001480468,0.000007577548,0.00004242732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003957094,0.00003565188,0.0004146958,0.00005878937,0.000007471835,0.00009768255,0.00001238003,0.00002802311,0.9981145,0.00006816877,0.00003915809,0.0007277701],"study_design_scores_gemma":[0.0001691824,0.001729774,0.02250531,0.00002006458,0.00006474573,0.001489615,0.0001065365,0.001186546,0.9685603,0.000128967,0.004030233,0.000008620695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958098,0.001402319,0.00164194,0.0001018947,0.0000625516,0.00002398679,0.0002363392,0.00003904916,0.0006821796],"genre_scores_gemma":[0.9978945,0.0004180007,0.0006751356,0.00004539131,0.000009984744,0.0000210653,0.0001958696,0.000005569943,0.000734537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001583703,"threshold_uncertainty_score":0.005298018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01247856736832955,"score_gpt":0.2630299600547412,"score_spread":0.2505513926864116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}