{"id":"W4407349081","doi":"10.1111/liv.70022","title":"Acute Transient Aminotransferase Elevation is Common With Intrathecal Methotrexate, but Liver Injury is Infrequent","year":2025,"lang":"en","type":"article","venue":"Liver International","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; Center for Cancer Research","keywords":"Medicine; Methotrexate; Internal medicine; Liver injury; Gastroenterology; Incidence (geometry); Liver enzyme; Retrospective cohort study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003776621,0.000270334,0.0002349887,0.0002757079,0.0002580562,0.00005904983,0.0003483259,0.0003774652,0.002794973],"category_scores_gemma":[0.00001278595,0.0002546536,0.0001269819,0.0002808712,0.0001597191,0.0003364982,0.00004736637,0.0009640545,0.0001727347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000251427,"about_ca_system_score_gemma":0.0001204534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002638882,"about_ca_topic_score_gemma":0.0001007633,"domain_scores_codex":[0.9982811,0.000287379,0.0003929969,0.0004179278,0.0003159485,0.0003046004],"domain_scores_gemma":[0.9992073,0.0001609196,0.0001039512,0.000179886,0.0002306474,0.0001172879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01008635,0.003306758,0.02586569,0.0003387306,0.007053073,0.0005438592,0.01841402,0.0005730779,0.4500729,0.04489082,0.04104339,0.3978113],"study_design_scores_gemma":[0.002584564,0.0003022704,0.008815761,0.00008436308,0.0004437152,0.00005639773,0.0001018133,0.01606861,0.7866477,0.001347292,0.1831037,0.0004437757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658743,0.0001077154,0.01167371,0.003830426,0.001757041,0.0007043301,0.0006111479,0.0001279987,0.01531333],"genre_scores_gemma":[0.9822097,0.0004945671,0.0005874301,0.01242638,0.0002038901,0.0001362211,0.000111709,0.00001886615,0.003811221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3973675,"threshold_uncertainty_score":0.9999906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07329254810326553,"score_gpt":0.4099428364320221,"score_spread":0.3366502883287565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}