{"id":"W4407349403","doi":"10.1016/j.ebiom.2025.105579","title":"Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelination","year":2025,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute","funders":"Medical Research Council; Alzheimer’s Research UK; National Medical Research Council; National Research Foundation Singapore; National Institute for Health Research Southampton Biomedical Research Centre; Ministry of Health -Singapore; Agency for Science, Technology and Research; National Research Foundation; National Institute for Health and Care Research; Nestlé Nutrition Institute","keywords":"Neurology; Genotype; Obesity; Proteomics; Medicine; Bioinformatics; Brain development; Neuroscience; Biology; Genetics; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006228412,0.00009636862,0.0001715191,0.00008619147,0.0001278769,0.000004538208,0.0001264571,0.0001893587,0.000005029819],"category_scores_gemma":[0.0007711289,0.0000745163,0.00002484446,0.0002301145,0.00007300862,0.00000134436,0.0001215251,0.0001191464,0.000002903728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001080162,"about_ca_system_score_gemma":0.00007549589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005531323,"about_ca_topic_score_gemma":0.00006830257,"domain_scores_codex":[0.9991488,0.0001171514,0.0002879227,0.0002053615,0.00006992845,0.0001708754],"domain_scores_gemma":[0.999535,0.00005313686,0.0001258612,0.0001597642,0.00007994261,0.00004633513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001377687,0.0001540698,0.4568219,0.0000361239,0.0004027927,0.000001656442,0.003745704,0.0001071444,0.5086583,0.0005229324,0.001567269,0.02784434],"study_design_scores_gemma":[0.0007205353,0.0002892049,0.9762398,0.00003997394,0.00003083108,0.000002424579,0.0002070813,0.0002196134,0.01077415,0.0003664867,0.0110078,0.0001020906],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902405,0.001241767,0.0008525754,0.00658382,0.00008858968,0.0002995138,0.000005539998,0.00001044654,0.0006772886],"genre_scores_gemma":[0.9964144,0.00003728336,0.0005454664,0.002424568,0.0000592195,0.00001726867,0.0001273879,0.000008170478,0.0003661889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5194179,"threshold_uncertainty_score":0.3038687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003346573325977654,"score_gpt":0.2315013766392615,"score_spread":0.2281548033132838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}