{"id":"W4407353657","doi":"10.1158/0008-5472.can-24-1793","title":"The Brain-Penetrant Pan-ErbB Inhibitor Poziotinib Effectively Targets HER2+ Breast Cancer Brain Metastases","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Winnipeg; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Max Rady College of Medicine, University of Manitoba; CancerCare Manitoba Foundation; National Institutes of Health; Mitacs; Cancer Research Society","keywords":"Lapatinib; Brain metastasis; ErbB; Cancer research; Breast cancer; Medicine; Trastuzumab; Metastasis; ERBB3; Tyrosine-kinase inhibitor; Protein kinase B; In vivo; Cancer; Pharmacology; Epidermal growth factor receptor; Apoptosis; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000814459,0.0003217818,0.0002694442,0.0002173475,0.0001111813,0.00025718,0.000203523,0.0001639225,0.0007237659],"category_scores_gemma":[0.00006088883,0.0001039672,0.0001537433,0.0001944043,0.0001040338,0.0001664487,0.0001404563,0.0006475698,0.0001968733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003507414,"about_ca_system_score_gemma":0.0003124761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001354271,"about_ca_topic_score_gemma":0.003139291,"domain_scores_codex":[0.9999344,0.000008725645,0.000004481027,0.000008016538,0.00002411018,0.00002023641],"domain_scores_gemma":[0.9999771,0.000003217518,0.000004721838,0.000002804459,0.000004096712,0.00000800591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001619973,0.0001293536,0.0002506884,0.00004951271,0.00001338256,0.0000579687,0.000008893332,0.0003006394,0.9932038,0.0001358403,0.0002987175,0.005389263],"study_design_scores_gemma":[0.0001724831,0.001616412,0.006542119,0.00001035658,0.00005009646,0.0009232115,0.00002757531,0.002553804,0.9814608,0.0001170152,0.00651874,0.000007473101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912534,0.003159624,0.001712531,0.0001911605,0.00002289747,0.00006167323,0.0004597671,0.0001297154,0.003009201],"genre_scores_gemma":[0.9931071,0.002501981,0.001262944,0.00005770268,0.000005390813,0.0000444698,0.0009281774,0.000009795025,0.002082269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354271,"threshold_uncertainty_score":0.002692759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0386829827507961,"score_gpt":0.4128645391555423,"score_spread":0.3741815564047462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}