{"id":"W4407353657","doi":"10.1158/0008-5472.can-24-1793","title":"The Brain-Penetrant Pan-ErbB Inhibitor Poziotinib Effectively Targets HER2+ Breast Cancer Brain Metastases","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Winnipeg; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Max Rady College of Medicine, University of Manitoba; CancerCare Manitoba Foundation; National Institutes of Health; Mitacs; Cancer Research Society","keywords":"Lapatinib; Brain metastasis; ErbB; Cancer research; Breast cancer; Medicine; Trastuzumab; Metastasis; ERBB3; Tyrosine-kinase inhibitor; Protein kinase B; In vivo; Cancer; Pharmacology; Epidermal growth factor receptor; Apoptosis; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002861046,0.0003457747,0.0005520972,0.0002988181,0.0008781936,0.0001653239,0.000358493,0.0001171696,0.0007394025],"category_scores_gemma":[0.0006620041,0.0002134768,0.0002674767,0.001238345,0.0005709653,0.0001014622,0.0002311829,0.0008742125,0.000074022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000906239,"about_ca_system_score_gemma":0.001629212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006354903,"about_ca_topic_score_gemma":0.002221446,"domain_scores_codex":[0.9955803,0.001002616,0.0004066292,0.0007648069,0.001078039,0.00116763],"domain_scores_gemma":[0.9955206,0.002708103,0.00007680053,0.0007446258,0.0006252453,0.0003246062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00340744,0.0008210533,0.0100588,0.0006833224,0.002443659,0.000429799,0.0003692618,0.00003157894,0.02809097,0.004372102,0.5576351,0.391657],"study_design_scores_gemma":[0.009893992,0.001069657,0.2196406,0.001719563,0.0004436389,0.00010639,0.0009010787,0.0001030726,0.0793523,0.001144458,0.6850982,0.0005270501],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6510816,0.06817607,0.0001450518,0.2699818,0.001380523,0.004685577,0.001573109,0.0001686112,0.002807658],"genre_scores_gemma":[0.9784949,0.002971623,0.0001376158,0.003105505,0.000735188,0.00135172,0.00005442388,0.00007106899,0.01307793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3911299,"threshold_uncertainty_score":0.9606754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0386829827507961,"score_gpt":0.4128645391555423,"score_spread":0.3741815564047462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}