{"id":"W4407362158","doi":"10.7554/elife.102274.3.sa0","title":"eLife Assessment: Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production","year":2025,"lang":"en","type":"peer-review","venue":"","topic":"Machine Learning in Bioinformatics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Mutant; Amyloid precursor protein; Amyloid precursor protein secretase; Amyloid (mycology); Peptide; β amyloid; P3 peptide; Chemistry; Alzheimer's disease; Biochemistry; Medicine; Internal medicine; Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007794254,0.0006795622,0.0007802961,0.0001433372,0.000154517,0.00008797914,0.0006836609,0.0005028645,0.0006573176],"category_scores_gemma":[0.0005674178,0.0006016577,0.0003550038,0.0002181218,0.0001330737,0.000007586224,0.0005885575,0.0007897021,0.00007864603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005547981,"about_ca_system_score_gemma":0.0006946405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001202236,"about_ca_topic_score_gemma":0.0001508628,"domain_scores_codex":[0.9968733,0.0002108091,0.0009691199,0.0008230601,0.0006254505,0.00049832],"domain_scores_gemma":[0.9972945,0.00002923118,0.0006093067,0.001418907,0.0004950179,0.0001529995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001628392,0.00007339021,0.00004210728,0.002560551,0.0005719829,0.000002588018,0.000007157775,0.00008605197,0.009062833,0.00011487,0.9837853,0.003676841],"study_design_scores_gemma":[0.0002387995,0.0001880843,0.0000532837,0.001172711,0.0005571136,0.0000363993,0.00001619581,0.0002884374,0.007063336,0.00001779631,0.9897168,0.000651102],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.001988778,0.1879749,0.02204353,0.09453382,0.016227,0.009916465,0.005523037,0.0008206448,0.6609718],"genre_scores_gemma":[0.00238128,0.07143179,0.04657765,0.02348657,0.003302482,0.0004129359,0.09982289,0.000238751,0.7523456],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1165432,"threshold_uncertainty_score":0.9996435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02274794960909088,"score_gpt":0.3392808370453246,"score_spread":0.3165328874362338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}