{"id":"W4407364121","doi":"10.7554/elife.103332.1","title":"Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of Osteoarthritis","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Bone and Joint Health Institute","funders":"Cumming School of Medicine, University of Calgary","keywords":"Osteoarthritis; Mesenchymal stem cell; Identification (biology); Population; Medicine; Biology; Pathology; Alternative medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002788957,0.0004780771,0.0005360617,0.0006631463,0.0001617938,0.0003117244,0.0001508233,0.0002926253,0.001124298],"category_scores_gemma":[0.0001288904,0.0001220463,0.0004137058,0.0002905725,0.0002578903,0.0002247946,0.0001369828,0.0007347104,0.0003248729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001596357,"about_ca_system_score_gemma":0.0002902787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005109186,"about_ca_topic_score_gemma":0.0009469538,"domain_scores_codex":[0.9997737,0.00002291762,0.00002497601,0.00003960232,0.00008054455,0.00005816292],"domain_scores_gemma":[0.9998461,0.00001511114,0.00003702003,0.00001462649,0.00003359262,0.00005349299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002530023,0.0001580638,0.0001875879,0.00004525984,0.00000667673,0.00002177262,0.00001675624,0.00004311966,0.9968488,0.00003839039,0.00003312187,0.002347544],"study_design_scores_gemma":[0.00006068696,0.005415662,0.005549589,0.0000121434,0.00007311669,0.0001358683,0.00008045293,0.0005996287,0.9866875,0.00003584228,0.001342873,0.00000666473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940388,0.00131239,0.003276012,0.000104767,0.00007569787,0.00008110346,0.0003474971,0.00007867334,0.000685026],"genre_scores_gemma":[0.9910043,0.00129795,0.003956327,0.00009043613,0.00003244614,0.000133622,0.0005102634,0.00001714732,0.002957306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124298,"threshold_uncertainty_score":0.003761113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03461970564916862,"score_gpt":0.3177105184196415,"score_spread":0.2830908127704729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}