{"id":"W4407366891","doi":"10.3390/pharmaceutics17020233","title":"Toxicity, Half-Life and Antitumor Activity of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as Novel Antimitotic CYP1A1-Targeted Prodrugs in Female Mouse Models","year":2025,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Hôpital Saint-François d'Assise","funders":"Fonds de Recherche du Québec - Santé; Canada Foundation for Innovation; Réseau Québécois de Recherche sur les Médicaments; Canadian Institutes of Health Research; Université Laval","keywords":"Prodrug; Pharmacology; Medicine; Paclitaxel; Toxicity; Chemotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001523632,0.0007697588,0.001163075,0.0007648157,0.0003251603,0.00007032797,0.0007771794,0.0005280752,0.0002404866],"category_scores_gemma":[0.000306157,0.0008175321,0.0002318433,0.001170768,0.0005532522,0.0004577522,0.0006725827,0.001553758,0.00002713098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000125121,"about_ca_system_score_gemma":0.0006347775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001496087,"about_ca_topic_score_gemma":0.00004376871,"domain_scores_codex":[0.9955746,0.0005733731,0.001132444,0.00100949,0.0004928443,0.00121725],"domain_scores_gemma":[0.9973475,0.0006934645,0.0004602863,0.0005248414,0.0003303186,0.0006436337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001300184,0.002770722,0.01500298,0.0007895791,0.0005596265,0.0000532844,0.001097069,0.01836333,0.9423175,0.01003109,0.0003482807,0.007366387],"study_design_scores_gemma":[0.006923607,0.00006164087,0.002208432,0.00006779347,0.0005037371,0.00002243404,0.0002126847,0.1342475,0.8437702,0.001901682,0.009380589,0.0006996748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811341,0.006041216,0.0005877775,0.001478406,0.001579035,0.001416651,0.0003182133,0.0001621803,0.00728238],"genre_scores_gemma":[0.987589,0.006945391,0.0006433501,0.00348335,0.0001889057,0.00009931748,0.00002999569,0.0000847991,0.0009359187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1158842,"threshold_uncertainty_score":0.9994276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1307785560044418,"score_gpt":0.4282220137369749,"score_spread":0.2974434577325331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}