{"id":"W4407369197","doi":"10.1016/j.cell.2025.01.025","title":"Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2","year":2025,"lang":"en","type":"article","venue":"Cell","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"American Hellenic Educational Progressive Association; National Cancer Institute; Manning Fund; Thompson Family Foundation; American Hellenic Educational Progressive Association Foundation; Memorial Sloan-Kettering Cancer Center; Hartwell Foundation; Children's Cancer and Blood Foundation; U.S. Department of Defense","keywords":"Biology; Integrin; Metastasis; Extracellular vesicles; Thrombosis; Cancer research; Lung cancer; Extracellular; Niche; Microvesicles; Vesicle; Cell biology; Immunology; Cancer; Internal medicine; Biochemistry; Genetics; Cell; Gene; microRNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002546369,0.0002878616,0.0002734339,0.00003329686,0.0002112014,0.00007924898,0.0004686226,0.0002130814,0.00008247518],"category_scores_gemma":[0.00008347791,0.0002326877,0.0001524482,0.0001951236,0.0002586379,0.000007345567,0.0003385096,0.0002406316,0.000009465125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005526522,"about_ca_system_score_gemma":0.0001374579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002942997,"about_ca_topic_score_gemma":0.0002080124,"domain_scores_codex":[0.9983192,0.0002435592,0.0003081961,0.0006103789,0.000165698,0.0003529444],"domain_scores_gemma":[0.9988784,0.0001024846,0.0001487144,0.0006675743,0.0000933794,0.0001094766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002261406,0.0002060285,0.02294303,0.00004706543,0.000433858,0.000004389794,0.0001991858,0.00003499374,0.9620206,0.00007825949,0.01258924,0.001420694],"study_design_scores_gemma":[0.000850567,0.00006112227,0.03071064,0.000080197,0.0007366448,5.727885e-7,0.0003413876,0.0007037796,0.9577932,0.0006750959,0.007684534,0.000362259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9459744,0.0500177,0.001524057,0.001161695,0.0002235126,0.0004489906,0.0001729743,0.00003304003,0.0004436334],"genre_scores_gemma":[0.9958391,0.001441333,0.0004877139,0.0005042164,0.0001008354,0.0000751289,0.0002429173,0.00003894279,0.001269838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04986468,"threshold_uncertainty_score":0.948873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01391449150418332,"score_gpt":0.271808526241529,"score_spread":0.2578940347373457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}