{"id":"W4407371890","doi":"10.1080/10715762.2025.2465277","title":"Nitric oxide is an irreversible human diamine oxidase inhibitor","year":2025,"lang":"en","type":"article","venue":"Free Radical Research","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"EQUIPMENT BOKU VIENNA INSTITUTE OF BIOTECHNOLOGY; Universität für Bodenkultur Wien; Medizinische Universität Wien; Universität Wien","keywords":"Diamine oxidase; Histamine; Nitric oxide; Extracellular; Chemistry; Mast cell; Oxidase test; Biochemistry; Diamine; Histamine N-methyltransferase; Enzyme; Pharmacology; Immunology; Histamine H2 receptor; Biology; Receptor; Organic chemistry; Antagonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003635937,0.0004708051,0.0002586665,0.0002171561,0.0002152289,0.0001814643,0.0003638156,0.0003223415,0.001737737],"category_scores_gemma":[0.0002371828,0.0001991021,0.0002515324,0.000122129,0.0001858449,0.0001739227,0.0002573149,0.0005931109,0.0005805488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002380968,"about_ca_system_score_gemma":0.0003127231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004684385,"about_ca_topic_score_gemma":0.0008877478,"domain_scores_codex":[0.9996768,0.0000691547,0.00002409956,0.00009686611,0.00008955166,0.00004365357],"domain_scores_gemma":[0.9998471,0.000022055,0.00004679801,0.00001581297,0.00002903325,0.00003907775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003482856,0.00009617724,0.0003441536,0.0003353572,0.00003083928,0.0001525102,0.00002176907,0.0001152327,0.9747593,0.0005949444,0.001262902,0.02193866],"study_design_scores_gemma":[0.0001226865,0.001922284,0.002956579,0.0000594602,0.00005803149,0.00130313,0.00001587764,0.001082959,0.9294221,0.0002074328,0.06283283,0.00001671187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6942629,0.1339403,0.110564,0.001722327,0.001854236,0.001340414,0.002906301,0.002130778,0.0512788],"genre_scores_gemma":[0.903017,0.02111435,0.03925567,0.0006807991,0.0002605329,0.0007508516,0.002805658,0.00009268782,0.03202253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001737737,"threshold_uncertainty_score":0.00581336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04982723559991059,"score_gpt":0.349628909598937,"score_spread":0.2998016739990264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}