{"id":"W4407380242","doi":"10.21203/rs.3.rs-4138879/v1","title":"A clinical drug candidate that triggers non-apoptotic cancer cell death","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Chemistry, Engineering and Medicine for Human Health, Stanford University; GlaxoSmithKline; National Institutes of Health; National Science Foundation","keywords":"Apoptosis; Drug; Programmed cell death; Cancer; Cancer drugs; Cancer research; Medicine; Pharmacology; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002405364,0.000380434,0.0005826625,0.0003602679,0.0003025497,0.0008151458,0.000233596,0.0008044695,0.008939078],"category_scores_gemma":[0.0004086506,0.0001216584,0.0003201475,0.0002656339,0.0002314102,0.000290411,0.0002798647,0.0007567501,0.001924142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003229463,"about_ca_system_score_gemma":0.0004793361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001203755,"about_ca_topic_score_gemma":0.0003287205,"domain_scores_codex":[0.9998512,0.00003301985,0.000007191791,0.0000292593,0.00004326418,0.0000361022],"domain_scores_gemma":[0.9998885,0.00002661891,0.00002282828,0.00001446937,0.00002018315,0.00002731244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004796423,0.001353365,0.002725883,0.001369206,0.0001660101,0.004265073,0.0001299761,0.001455769,0.6327592,0.0186959,0.02044157,0.3118418],"study_design_scores_gemma":[0.002595657,0.01308547,0.008467364,0.0003253056,0.0003566543,0.01510483,0.0001779436,0.004800624,0.6971684,0.01171496,0.2461491,0.00005369255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7636205,0.07889833,0.02680243,0.01381257,0.003662076,0.001371934,0.002452284,0.0009454382,0.1084344],"genre_scores_gemma":[0.9430194,0.01331059,0.006015774,0.001262716,0.000418128,0.000173746,0.0008148052,0.00006466033,0.03492024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008939078,"threshold_uncertainty_score":0.02990425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08813583159908801,"score_gpt":0.4397510662372602,"score_spread":0.3516152346381722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}