{"id":"W4407384944","doi":"10.1101/2025.02.07.637178","title":"The Landscape of Prostate Tumour Methylation","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Methylation; Prostate; Oncology; Medicine; Internal medicine; Biology; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003460178,0.0001075133,0.0002762722,0.0004744726,0.0001772749,0.0007680829,0.0001590879,0.0001719699,0.001405443],"category_scores_gemma":[0.0008084128,0.0001921161,0.0001489495,0.0005700383,0.0002269771,0.0002937594,0.0004889847,0.0002758692,0.0002943677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002692976,"about_ca_system_score_gemma":0.0002103984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008753751,"about_ca_topic_score_gemma":0.001633497,"domain_scores_codex":[0.9997426,0.00005725395,0.000009963876,0.0001027176,0.0000536385,0.00003376945],"domain_scores_gemma":[0.9998048,0.0000558441,0.000058704,0.00003364009,0.00002798346,0.00001898015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004654916,0.00002354677,0.2438199,0.0003324083,0.0003287562,0.0003016405,0.00087728,0.005206632,0.5694293,0.007218133,0.001928119,0.1700689],"study_design_scores_gemma":[0.00001451338,0.0001893721,0.8666954,0.00006240119,0.0001620907,0.001639259,0.0004411638,0.01373374,0.07847444,0.01251878,0.02600724,0.0000615622],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977217,0.005045288,0.008766172,0.0004368323,0.00001370682,0.00001151278,0.002805873,0.0001438355,0.005559728],"genre_scores_gemma":[0.9942753,0.00114293,0.002006911,0.00008950255,0.00001383158,0.00001035382,0.001234302,0.00003379916,0.001193138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001405443,"threshold_uncertainty_score":0.004701674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01824478319039256,"score_gpt":0.2763016088933691,"score_spread":0.2580568257029765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}