{"id":"W4407387126","doi":"10.1093/ijnp/pyae059.134","title":"PSILOCYBIN MITIGATES BEHAVIORAL DESPAIR AND COGNITIVE RECOGNITION IMPAIRMENTS BY REGULATING THE HYPOTHALAMIC- PITUITARY-ADRENAL (HPA) AXIS VIA THE BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) SIGNALING PATHWAY MEDIATED BY THE ENDOCANNABINOID SYSTEM (ECS)","year":2025,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Brain-derived neurotrophic factor; Neuroscience; Endocannabinoid system; Neurotrophic factors; Psychology; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195029,0.0005147191,0.000408976,0.0002796529,0.0001617641,0.000185195,0.0002719137,0.0003158094,0.001973627],"category_scores_gemma":[0.0001071411,0.0001169956,0.0003082684,0.0001136157,0.0003359077,0.0002512706,0.0002201878,0.001137325,0.0001849908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001994547,"about_ca_system_score_gemma":0.0003242256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00094327,"about_ca_topic_score_gemma":0.001817632,"domain_scores_codex":[0.9999306,0.00001182926,0.000006218234,0.00001244444,0.00001531359,0.00002368057],"domain_scores_gemma":[0.9999201,0.000005292734,0.00002868192,0.000007334288,0.00001070117,0.00002775528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01404898,0.004004329,0.001709399,0.001157923,0.0002365288,0.0002634524,0.00009124054,0.000306391,0.9312214,0.0006292668,0.001406268,0.04492485],"study_design_scores_gemma":[0.005355895,0.1245304,0.1167025,0.000594482,0.0009881451,0.001258962,0.0008504156,0.006283706,0.7190039,0.002207889,0.02210195,0.0001217418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904101,0.005435504,0.0013465,0.000461687,0.0001466837,0.00007804733,0.0003388381,0.0001243554,0.001658195],"genre_scores_gemma":[0.9908128,0.005048775,0.0009454806,0.0003445856,0.00005215343,0.0001135281,0.0003302775,0.00001017343,0.00234214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001973627,"threshold_uncertainty_score":0.006602466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02521550549453345,"score_gpt":0.3206089855521677,"score_spread":0.2953934800576342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}