{"id":"W4407387203","doi":"10.1093/ijnp/pyae059.640","title":"THE EFFECT OF FOOD ON THE PHARMACOKINETICS OF A SINGLE ORAL DOSE OF ICLEPERTIN (BI 425809), A GLYCINE TRANSPORTER 1 INHIBITOR, IN HEALTHY VOLUNTEERS: A PHASE I OPEN-LABEL, RANDOMIZED, CROSSOVER TRIAL","year":2025,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Open label; Pharmacokinetics; Crossover study; Pharmacology; Transporter; Randomized controlled trial; Medicine; Glycine; Bioequivalence; Chemistry; Internal medicine; Biochemistry; Placebo; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001572415,0.001785793,0.00281088,0.0003994522,0.0005873996,0.000851287,0.0007103667,0.001921481,0.005078881],"category_scores_gemma":[0.001810881,0.0009106949,0.00112968,0.0003374886,0.001104535,0.001129941,0.0003471914,0.002141928,0.0008466072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005756766,"about_ca_system_score_gemma":0.001063724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007543496,"about_ca_topic_score_gemma":0.001345297,"domain_scores_codex":[0.9991985,0.0003951054,0.00005467578,0.0001843677,0.00005874146,0.0001086227],"domain_scores_gemma":[0.9987454,0.0003207,0.0002660574,0.0001043867,0.0001002946,0.0004631093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9759405,0.01095733,0.0003032419,0.0001694951,0.0002606156,0.0000266736,0.00003577736,0.0001164835,0.005900778,0.00002617945,0.0002292711,0.006033592],"study_design_scores_gemma":[0.6265094,0.3677106,0.003033751,0.00001394087,0.0003613297,0.00003305914,0.0000260534,0.0004668611,0.001327354,0.00006445833,0.0004282667,0.00002501714],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952559,0.001002564,0.0003773278,0.0001523308,0.0002037059,0.001767752,0.0004055805,0.00007102699,0.0007637836],"genre_scores_gemma":[0.9925321,0.0008260028,0.001113897,0.000420005,0.000307586,0.002327783,0.0004112806,0.00002670258,0.002034754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005078881,"threshold_uncertainty_score":0.01699054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06870660556761159,"score_gpt":0.4455730358776827,"score_spread":0.3768664303100711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}