{"id":"W4407388962","doi":"10.1080/15548627.2025.2465183","title":"ESRRA (estrogen related receptor, alpha) induces ribosomal protein RPLP1-mediated adaptive hepatic translation during prolonged starvation","year":2025,"lang":"en","type":"article","venue":"Autophagy","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences; Duke-NUS Medical School; Medical Research Council; Ministry of Health -Singapore; National Medical Research Council; Louisiana Clinical and Translational Science Center; National Cancer Institute; National Institutes of Health","keywords":"Biology; Starvation; Estrogen receptor alpha; Translation (biology); Alpha (finance); Estrogen receptor; Receptor; Estrogen; Ribosomal protein; Cell biology; Protein biosynthesis; Endocrinology; Internal medicine; Ribosome; Molecular biology; Messenger RNA; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001383282,0.0002371267,0.0002203923,0.0000925556,0.0001354589,0.00002663948,0.0001958565,0.0003019075,0.00003812124],"category_scores_gemma":[0.0001317762,0.000251562,0.00009711264,0.0002228649,0.0001021557,0.00001707667,0.00006074858,0.0001908896,0.00002243945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000521559,"about_ca_system_score_gemma":0.0001368176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002860088,"about_ca_topic_score_gemma":0.000019402,"domain_scores_codex":[0.9985215,0.000130918,0.0003906167,0.000505276,0.0001394548,0.0003122347],"domain_scores_gemma":[0.9993272,0.000020512,0.0001708592,0.0002832562,0.0001299054,0.00006825773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002696806,0.00008591238,0.00104817,0.00004310278,0.0001517316,0.000001705232,0.0001940471,0.00003930173,0.9959328,0.0002630232,0.00005588611,0.001914661],"study_design_scores_gemma":[0.001265434,0.0001824104,0.01779605,0.00005698222,0.00003148465,0.00000145921,0.00007443511,0.0002016319,0.9788746,0.0004981011,0.0007818173,0.0002355598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964187,0.001245437,0.0003746318,0.0002616477,0.0001522024,0.0008375308,0.00005180268,0.00005699747,0.0006010776],"genre_scores_gemma":[0.996902,0.00004751035,0.001347492,0.00006768951,0.00009373426,0.0001735323,0.000743053,0.00002699908,0.0005980199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01705814,"threshold_uncertainty_score":0.9999937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008981464628474508,"score_gpt":0.2300292812204514,"score_spread":0.2210478165919769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}