{"id":"W4407392464","doi":"10.1158/1078-0432.ccr-24-3278","title":"Update on Cancer and Central Nervous System Tumor Surveillance in Pediatric <i>NF2</i> -, <i>SMARCB1</i> -, and <i>LZTR1</i> -Related Schwannomatosis","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Manchester Biomedical Research Centre; National Cancer Institute; National Institutes of Health; Deutsche Kinderkrebsstiftung; American Lebanese Syrian Associated Charities; National Institute for Health and Care Research; Department of Health and Social Care; Servier; Hospital Research Foundation; Alexion Pharmaceuticals","keywords":"Neurofibromatosis type 2; SMARCB1; Medicine; Schwannoma; Neurofibromatoses; Meningioma; Acoustic neuroma; Oncology; Pathology; Internal medicine; Neurofibromatosis; Surgery; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002153134,0.0005716537,0.001327768,0.003783304,0.0004276431,0.00146228,0.001146466,0.002160742,0.003320284],"category_scores_gemma":[0.007065739,0.0004062182,0.0008849018,0.003708836,0.0004523624,0.002336958,0.0008775798,0.003230242,0.001608971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001766918,"about_ca_system_score_gemma":0.002289002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006471558,"about_ca_topic_score_gemma":0.01813998,"domain_scores_codex":[0.9988582,0.0003122079,0.0003078742,0.0001061582,0.0003208531,0.00009461978],"domain_scores_gemma":[0.9924614,0.003225672,0.001006593,0.0001403868,0.002545904,0.0006200748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00007867699,0.00005042031,0.003080712,0.004263795,0.0001045606,0.0006377591,0.000140755,0.0004343384,0.0004021853,0.00136303,0.399085,0.5903587],"study_design_scores_gemma":[0.00002301578,0.0000834411,0.005316441,0.006863109,0.0002122873,0.002862686,0.0001567414,0.0001854379,0.0001383854,0.0005699359,0.9835612,0.00002738428],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.001716996,0.9278966,0.001376563,0.03893391,0.01535649,0.00006531463,0.0008636944,0.0002159828,0.01357457],"genre_scores_gemma":[0.007445526,0.9396455,0.003284483,0.02035972,0.02239077,0.0001045848,0.001929051,0.00004926834,0.004791055],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006471558,"threshold_uncertainty_score":0.01286775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05832093385520565,"score_gpt":0.4134866590835648,"score_spread":0.3551657252283592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}