{"id":"W4407393488","doi":"10.3390/molecules30040826","title":"Antibiofilm Activities of Tritrpticin Analogs Against Pathogenic Pseudomonas aeruginosa PA01 Strains","year":2025,"lang":"en","type":"article","venue":"Molecules","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; University of Calgary","keywords":"Pseudomonas aeruginosa; Biofilm; Chemistry; Peptide; Staphylococcus aureus; Cathelicidin; Amino acid; Antimicrobial peptides; Antimicrobial; Peptide sequence; Biochemistry; Pathogenic bacteria; Residue (chemistry); Bacteria; Stereochemistry; Microbiology; Biology; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001843882,0.0003356948,0.0003486729,0.000193394,0.00009038419,0.0001960026,0.0002379897,0.0003152487,0.0008523026],"category_scores_gemma":[0.0003176375,0.00009154156,0.000228671,0.0001957294,0.000123019,0.0002130364,0.0002194458,0.0006870499,0.000189499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009150875,"about_ca_system_score_gemma":0.0001041889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000233861,"about_ca_topic_score_gemma":0.0002274028,"domain_scores_codex":[0.9997675,0.00005716126,0.00003858702,0.00003433699,0.00007391984,0.00002847636],"domain_scores_gemma":[0.9996799,0.00009662569,0.00008139112,0.00002835656,0.00005682954,0.00005683502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007929392,0.00005695455,0.0000753558,0.00004328921,0.000004414143,0.00004037303,0.00001420412,0.00007407538,0.998467,0.000009512723,0.00001313896,0.001122376],"study_design_scores_gemma":[0.00002057821,0.002148575,0.00190911,0.000007230661,0.00001633618,0.0003637166,0.00003424755,0.0007636973,0.9939977,0.00001587994,0.0007136846,0.000009258058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977659,0.0008734612,0.0007461266,0.00003830432,0.00001448114,0.00002674965,0.0001124554,0.00001507615,0.0004074475],"genre_scores_gemma":[0.9943191,0.0007919037,0.003757633,0.00006533209,0.00001461856,0.00004611545,0.0003373748,0.00001385534,0.00065405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008523026,"threshold_uncertainty_score":0.002851307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008075923281959562,"score_gpt":0.229989728406218,"score_spread":0.2219138051242585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}