{"id":"W4407393488","doi":"10.3390/molecules30040826","title":"Antibiofilm Activities of Tritrpticin Analogs Against Pathogenic Pseudomonas aeruginosa PA01 Strains","year":2025,"lang":"en","type":"article","venue":"Molecules","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; University of Calgary","keywords":"Pseudomonas aeruginosa; Biofilm; Chemistry; Peptide; Staphylococcus aureus; Cathelicidin; Amino acid; Antimicrobial peptides; Antimicrobial; Peptide sequence; Biochemistry; Pathogenic bacteria; Residue (chemistry); Bacteria; Stereochemistry; Microbiology; Biology; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269938,0.0002358037,0.0004481559,0.0002253495,0.0001590811,0.00002032801,0.0002405375,0.000229161,0.0001206022],"category_scores_gemma":[0.0000440994,0.0002180382,0.0002255494,0.0002088318,0.0005024445,0.00009219585,0.000113177,0.0002396778,0.00003319763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002581727,"about_ca_system_score_gemma":0.0001156339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001263472,"about_ca_topic_score_gemma":0.00004909006,"domain_scores_codex":[0.9988016,0.0001400097,0.000337812,0.0003037801,0.00003653757,0.0003801972],"domain_scores_gemma":[0.9993961,0.000103323,0.0001411986,0.0002944135,0.00004892856,0.00001597449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006980828,0.0001674646,0.001008656,0.00007077812,0.0002348737,0.00001266032,0.000212482,0.00001798801,0.9812682,0.005461685,0.003311107,0.008164247],"study_design_scores_gemma":[0.0009454932,0.0001108514,0.008260476,0.0001439862,0.00008050237,0.00001246076,0.001341872,0.000007942939,0.9859188,0.0003189427,0.002617994,0.000240661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866434,0.001940809,0.0009234869,0.0002405821,0.0003369502,0.0001842827,0.0002341559,0.00007460773,0.009421753],"genre_scores_gemma":[0.9950834,0.0003053462,0.000312171,0.0004056873,0.00001689736,0.000005607073,0.0001226068,0.0000156282,0.003732692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008439991,"threshold_uncertainty_score":0.8891339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008075923281959562,"score_gpt":0.229989728406218,"score_spread":0.2219138051242585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}