{"id":"W4407394865","doi":"10.1016/j.lanmic.2024.101000","title":"Safety and immunogenicity of an adjuvanted chikungunya virus virus-like particle (CHIKV VLP) vaccine in previous recipients of other alphavirus vaccines versus alphavirus vaccine-naive controls: an open-label, parallel-group, age-matched, sex-matched, phase 2 randomised controlled study","year":2025,"lang":"en","type":"article","venue":"The Lancet Microbe","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nordic Life Science Pipeline (Canada)","funders":"U.S. Army Medical Research Institute of Infectious Diseases; Uniformed Services University of the Health Sciences; Defense Health Agency; U.S. Department of Defense","keywords":"Alphavirus; Immunogenicity; Virology; Chikungunya; Virus; Togaviridae; Serotype; Virus-like particle; Medicine; Biology; Immunology; Immune system; Recombinant DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002503826,0.0007938116,0.00439445,0.0002123325,0.0002304523,0.0001183561,0.001284067,0.0002231132,0.0002311212],"category_scores_gemma":[0.0004205561,0.0005651603,0.0002732964,0.0006793042,0.0001160323,0.0004236337,0.00050603,0.0005095214,0.000007255763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001266628,"about_ca_system_score_gemma":0.0001851665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004501211,"about_ca_topic_score_gemma":0.004659321,"domain_scores_codex":[0.9937495,0.001533975,0.002320323,0.001050887,0.00043105,0.000914296],"domain_scores_gemma":[0.9957345,0.0007748689,0.001008742,0.001863227,0.0003103754,0.0003082647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5706646,0.0117815,0.01203954,0.0001102505,0.002292533,0.00008623079,0.001461664,0.00005744632,0.394641,0.00005169404,0.0001410878,0.00667239],"study_design_scores_gemma":[0.9224589,0.006307976,0.04727616,0.0003601805,0.003722557,0.00001610006,0.001321457,0.004114449,0.01312724,0.00010897,0.000588564,0.0005974232],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773714,0.009950653,0.0001448574,0.000346547,0.0003011359,0.01114535,0.0004996964,0.000102563,0.0001377967],"genre_scores_gemma":[0.9958399,0.001178971,0.0002218951,0.001449378,0.0001722845,0.0006837283,0.0001246981,0.0000948961,0.0002342326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3815138,"threshold_uncertainty_score":0.99968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03110945869678534,"score_gpt":0.3488738267498314,"score_spread":0.317764368053046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}