{"id":"W4407394865","doi":"10.1016/j.lanmic.2024.101000","title":"Safety and immunogenicity of an adjuvanted chikungunya virus virus-like particle (CHIKV VLP) vaccine in previous recipients of other alphavirus vaccines versus alphavirus vaccine-naive controls: an open-label, parallel-group, age-matched, sex-matched, phase 2 randomised controlled study","year":2025,"lang":"en","type":"article","venue":"The Lancet Microbe","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nordic Life Science Pipeline (Canada)","funders":"U.S. Army Medical Research Institute of Infectious Diseases; Uniformed Services University of the Health Sciences; Defense Health Agency; U.S. Department of Defense","keywords":"Alphavirus; Immunogenicity; Virology; Chikungunya; Virus; Togaviridae; Serotype; Virus-like particle; Medicine; Biology; Immunology; Immune system; Recombinant DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002997514,0.001045959,0.002559174,0.000318119,0.0003525463,0.0008856581,0.0007284679,0.001548759,0.003016174],"category_scores_gemma":[0.002929972,0.0006423291,0.001680134,0.0003347895,0.0009451957,0.001032095,0.0004045172,0.0016546,0.0003766359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007626387,"about_ca_system_score_gemma":0.0009926992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005567921,"about_ca_topic_score_gemma":0.0008948317,"domain_scores_codex":[0.9988226,0.0005522241,0.0001236365,0.0002409586,0.000133236,0.00012739],"domain_scores_gemma":[0.9982384,0.0005251361,0.0005656942,0.0001203081,0.0001294384,0.0004208905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9674782,0.01119014,0.003907627,0.001078185,0.001656644,0.00004027606,0.00008166039,0.0001788471,0.003372154,0.0000347904,0.0002060871,0.01077538],"study_design_scores_gemma":[0.6470651,0.3397669,0.01046228,0.00008794654,0.001130404,0.00006323217,0.00003798251,0.0002841439,0.0006485189,0.00007562828,0.0003597202,0.00001816583],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954771,0.002526039,0.0001689963,0.00007483231,0.0001424172,0.001127973,0.0001820061,0.00001339453,0.0002872048],"genre_scores_gemma":[0.9946824,0.00153238,0.0004387517,0.0002094692,0.0002268635,0.002047315,0.0002753308,0.000004858067,0.0005826729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003016174,"threshold_uncertainty_score":0.01585257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03110945869678534,"score_gpt":0.3488738267498314,"score_spread":0.317764368053046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}